Police were called to a Canterbury Hospital at 8.45am after a man showed up to the ER with stab wounds to the head.
Officers were told that just 45 minutes before, the 34-year-old had been assaulted by three men, with at least one known to him.
The alleged attack happened inside a unit on Beamish Street in Campise.
A later search of the unit uncovered three machetes, police say.
The man and a woman known to him rode to the hospital for treatment on a motorcycle.
Police seized the bike for forensic testing.
Investigators believe it was a targeted attack.
Following investigations, three men aged, 43, 44 and 45, were arrested from Beamish Street.
All three were charged with wounding a person with the intent to cause grievous bodily harm.
The 44-year-old man was also charged with possessing a prohibited drug.
All three men were refused bail to appear before Parramatta Local Court today.
