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Mam was driving on Simpson Road in Bardon, a western suburb of Brisbane, when his Ford Ranger ute crashed head-on into a Toyota Camry being used as an Uber at 5pm on October 18.
Uber driver Marcel Van Den Camp, 64, and a four-year-old girl who was a passenger were injured in the crash.
Mam was given a roadside drug test at the scene of the crash which allegedly returned a positive result.
He was detained and taken for a second blood test at a hospital.
Police said the second test result had come back positive for drugs yesterday.
Mam had checked himself into rehab while police investigated the crash.
Today, police issued the 21-year-old NRL star with a notice to appear in court through his solicitor.
He has been charged with one count of driving while a drug was present in his blood and one count of driving without a licence.
He was also hit with a traffic infringement notice for failing to keep control of a vehicle.
Mam has been issued a notice to appear in Brisbane Magistrates Court on December 16.
Mam remains a Broncos player and the crash was referred to the NRL integrity unit. 
In the days after the crash, Broncos CEO Dave Donaghy urged Mam to accept responsibility for his actions.
”Ezra is a young man, he’s a 21-year-old,” Donaghy told 4BC radio in the days after the crash.
“Unfortunately, in this industry, you need to grow up quickly.
“That’s the price of entry. It’s a very privileged role.
“I am big on personal responsibility and accountability. I am sure there will be that opportunity once the full facts are known.”