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Donald Trump has held back global efforts to find real treatments, SAGE scientists claims

Sir Jeremy Farrar said today the US President's enthusiasm about hydroxychloroquine had held back global efforts to find Covid-19 treatments

Sir Jeremy Farrar said today the US President's enthusiasm about hydroxychloroquine had held back global efforts to find Covid-19 treatments

Sir Jeremy Farrar said today the US President’s enthusiasm about hydroxychloroquine had held back global efforts to find Covid-19 treatments

Donald Trump‘s endorsement of hydroxychloroquine as a coronavirus wonder drug has slowed down global efforts to beat the disease, a UK Government scientist suggested today.

Sir Jeremy Farrar implied the US President’s enthusiasm about the anti-malaria drug — which has since been proven not to have any effect on Covid-19 patients — ‘delayed and slowed down our progress in developing treatments’.

Trump first touted hydroxychloroquine in April, saying there were ‘very strong signs’ it could treat the viral disease based on limited anecdotal reports from US doctors and poor studies.

But last month, Oxford University’s Recovery trial, the biggest in the world, stopped enrolling participants to its hydroxychloroquine arm after concluding that it showed no clinical benefit.

President Trump has also admitted to taking the drug as a preventative therapy, to stop him from getting infected from the disease in the first place. Trials are currently ongoing to see if the tablets can work in this way.

Sir Jeremy, a member of Downing Street’s Scientific Advisory Group for Emergencies (Sage), said out of more than a thousand clinical trials of Covid-19 treatments around the world, 16 per cent are looking at hydroxychloroquine. 

He told a Chatham House briefing it ‘didn’t make any organised sense’ and blamed comments politicians for making statements about ‘certain drugs’ which proved not to be true and holding back progress of other potential therapies.

Trump first touted hydroxyhcloroquine in April, saying there were 'very strong signs' it could treat the viral disease based on very limited anecdotal reports from US doctors

Trump first touted hydroxyhcloroquine in April, saying there were 'very strong signs' it could treat the viral disease based on very limited anecdotal reports from US doctors

Trump first touted hydroxyhcloroquine in April, saying there were ‘very strong signs’ it could treat the viral disease based on very limited anecdotal reports from US doctors

The anti-malaria drug has since been proven not to have any effect on Covid-19 patients

The anti-malaria drug has since been proven not to have any effect on Covid-19 patients

The anti-malaria drug has since been proven not to have any effect on Covid-19 patients

Only one drug — the £5 steroid dexamethasone — has been conclusively proven to treat coronavirus. Ebola drug remdesivir has been approved to treat patients but the evidence is still mixed.

The Recovery trial found it reduced the risk of death by 35 per cent for patients relying on ventilators — the most dangerously ill — and by a fifth for all patients needing oxygen at any point.

Sir Jeremy said today: ‘I think there are 1,200 clinical trials currently in place around the world, of which 16 per cent are looking at chloroquine or hydroxychloroquine. That doesn’t make any organised sense.’

He suggested statements made by politicians in relation to drugs, which ended up not being true, had ‘delayed and slowed down our progress in developing treatments’. But he did not name any politicians in particular.

Sir Jeremy, who is also director of the Wellcome Trust, a research-charity based in London, claimed too many trials of potential treatments were too small to show definitive results.

He praised the Recovery trial — which has recruited 11,000 trialists — and the World Health Organization’s Solidarity trial, which has 5,000 volunteers.

But he added: ‘Many of the trials, and I think here the clinical community does need to take a harsh look at ourselves, many of the trials are too small. 

‘I think 40 pre cent will enrol less than 100 patients. It’s very unlikely in less than 100 patients you’re going to provide definitive evidence of the efficacy and safety of a treatment. 

VACCINE NATIONALISM ‘HAS NO PLACE’ IN THE COVID-19 FIGHT 

Sir Jeremy Farrar, who is a member of the Scientific Advisory Group for Emergencies (Sage), also warned against ‘nationalism’ when it comes to treatments and a vaccine.

He said the pandemic will affect all of us ‘until every country manages to steer a way through it’, adding: ‘So there’s no point being nationalistic, there’s no point saying “I’ve got my vaccine in America and nobody else will have it”, because that won’t work, and it won’t actually protect Americans.

‘Vaccine nationalism, therapeutic nationalism, has no place in enlightened self-interest, and they have to be seen as global public goods.’ 

His comments come after Donald Trump was earlier this month accused of ‘undermining’ the global Covid-19 fight by splashing the cash on one of only two drugs approved to treat the disease on the NHS. 

The US Department of Health and Human Services (HSS) revealed it had secured more than 500,000 treatment courses of remdesivir for American hospitals.

It represented the entire global supply for July and 90 per cent of stocks for August and September, leading to fears of an autumn shortage.   

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‘You have to do things at scale as Recovery and Solidarity have done, and small trials will often be unhelpful, and will often be politicised as we have seen in this epidemic, where politicians sadly made statements about certain drugs which proved not to be true and I think delayed and slowed down our progress in developing treatments.’ 

Last month Oxford University scientists pulled the controversial drug from the Recovery trial after results showed it had no benefit on patients hospitalised with the virus.

A quarter of NHS patients given hydroxychloroquine died from Covid-19, compared to 23.5 per cent who were not prescribed the drug.

The scientists running the trial said the results were ‘pretty compelling’, adding: ‘This isn’t a treatment that works.’

Professor Martin Landray, lead author of the study, added: ‘If you’re admitted to hospital with Covid – you, your mother or anyone else — hydroxychloroquine is not the right treatment. It doesn’t work.’

He called for doctors around the world to stop using the drug, which can cause a slew of nasty side effects including heart arrhythmias, headaches and vomiting. 

But Professor Landray said the results do not necessarily mean the tablets cannot prevent people from catching Covid-19 in the first place, which several studies are still investigating. 

Early results on hydroxychloroquine from the RECOVERY trial were not supposed to released until July. 

But the study’s chief investigators said they felt compelled to release the data and set the record straight on the drug, which has been at the centre of furious debate. 

It comes after another study last week claimed that hydroxychloroquine can boost survival odds for some coronavirus patients.

Hospitalized coronavirus patients given hydroxychloroquine were 50 percent less likely to die of the brutal infection than those who did not receive the drug.

President Trump’s top economic adviser Peter Navarro claimed the US ‘could have saved 10s of thousands of lives’ if it used the drug from the start. 

But critics slammed the Henry Ford Health System retrospective analysis of 2,541 people, saying it wasn’t a randomised trial — the gold-standard type of scientific evidence.

Exerts warned more of the hydroxychloroquine group were given steroids, which data suggests combats dangerous inflammation in coronavirus patients.

WHY IS HYDROXY-CHLOROQUINE CONTROVERSIAL? 

Hydroxychloroquine – branded as Plaquenil – is a cheap drug that has been used to prevent malaria and treat lupus and rheumatoid arthritis for decades.

It was touted as a wonder drug by Donald Trump despite no evidence it could treat Covid-19. 

Hope was sparked early on in the crisis when a French study suggested the drug could have both antiviral and anti-inflammatory effects.

It triggered a flurry of research across the world, the endorsement from Trump and emergency authorization from US regulators.

The RECOVERY trial is the first randomised study to provide concrete evidence about the drug.

The results will likely have a knock-on effect around the globe, where tens of thousands of coronavirus patients are still being prescribed hydroxychloroquine. 

Leading doctors have also warned the drug can cause severe side effects, and can even throw off the process that makes the heart beat in time.

One trial in Brazil was stopped short because so many of the enrolled coronavirus patients given the drug developed these arrhythmias (abnormal heartbeats).

According to WebMD, side effects may include: 

  • Nausea, vomiting, loss of appetite, diarrhea, dizziness, or headache
  • Slow heartbeat, symptoms of heart failure (such as shortness of breath, swelling ankles/feet, unusual tiredness, unusual/sudden weight gain)
  • Mental/mood changes (such as anxiety, depression, rare thoughts of suicide, hallucinations)
  • Hearing changes (such as ringing in the ears, hearing loss), easy bruising/bleeding
  • Signs of infection or liver disease
  • Muscle weakness, unwanted/uncontrolled movements (including tongue/face twitching), hair loss, hair/skin color changes
  • Low blood sugar, severe dizziness, fainting, fast/irregular heartbeat, seizures.
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Source: Daily Mail

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