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Vaping is significantly less harmful than smoking but not harm-free (Image: Getty)
Nicotine-based vapes are likely to increase the risk of cancers affecting the lungs and mouth or throat, Australian researchers have concluded. A team of experts from a range of fields, including pharmacy, epidemiology, thoracic surgery and public health, reviewed evidence from previous studies and laboratory research.
Australian researchers have determined that nicotine-based vaping products may elevate the risk of developing cancers in the lungs, mouth, or throat. This conclusion was reached by a multidisciplinary team, including specialists in pharmacy, epidemiology, thoracic surgery, and public health, who meticulously examined data from prior studies and laboratory experiments.
According to Professor Bernard Stewart from the University of New South Wales, who led the study, “We believe this review provides the clearest evidence yet that vaping increases cancer risk compared to non-vaping. By integrating insights from clinical observations, animal research, and mechanistic analyses, it’s evident that e-cigarettes likely contribute to the development of lung and oral cancers.”
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Although e-cigarettes are often touted as being about 95% less harmful than traditional smoking methods, primarily because they deliver nicotine without the combustion of tobacco, they are not without risk. This method avoids the production of tar and carbon monoxide, which are among the most harmful components in tobacco smoke.
Vaping has been recommended as a tool to help adults quit smoking. However, health experts have stressed that vaping is not harmless, and people who do not smoke should not start vaping.
The researchers noted that colourful, flavoured devices have spread quickly and widely, becoming a common sight outside schools, bars and train stations.
Study co-author Professor Freddy Silas, also of UNSW, said e-cigarettes could also act as a gateway to smoking.
He added: “But the extent to which they may cause cancer in their own right has not received as much attention in research.
“The evidence was remarkably consistent across fields. It dictated an unequivocal finding now, though human studies that estimate the risk will take decades to accumulate.”
E-cigarettes can help people quit smoking (Image: Getty)
The team identified numerous carcinogenic compounds in e-cigarette aerosols, including volatile organic chemicals and metals released from heating coils.
They also examined evidence of biomarkers in people showing DNA damage, oxidative stress and tissue inflammation; experiments in mice that caused lung tumours; and laboratory studies showing cellular damage and disrupted biological pathways linked to cancer.
Writing in the journal Carcinogenesis, the researchers concluded: “Nicotine-based e-cigarettes are likely to be carcinogenic to humans who use them, causing an indeterminate burden of oral cancer and lung cancer.”
The review also included researchers from The University of Queensland, Flinders University and The University of Sydney, and Royal North Shore, The Prince Charles and Sunshine Coast University hospitals.
