This contest represents the inaugural Week 1 clash between the quarterbacks who finished as the top two in the MVP race the prior season, based on NBC Sports research. As the new season kicks off, the key question isn’t about whether Jackson or Allen will outperform each other, but if either can finally guide their team past Kansas City.

Navigating to the Super Bowl in the AFC has necessitated facing the Chiefs, who have appeared in the conference championship game for six straight seasons. This streak includes twice thwarting the Bills from a Super Bowl berth (in the 2020 and 2024 seasons) and denying the Ravens once (in 2023).

It’s rare for quarterbacks of Jackson and Allen’s caliber to have not competed for a league title at this stage in their careers. Out of 28 Pro Football Hall of Fame quarterbacks, 22 had participated in either the Super Bowl or the NFL championship (before the Super Bowl era) within their first seven seasons, according to Stathead. This highlights the formidable stronghold the Chiefs have on the AFC under the leadership of coach Andy Reid and quarterback Patrick Mahomes.

Since both Allen and Jackson entered the league together in 2018, Baltimore is 1-4 against Kansas City, including 0-1 in the playoffs, while allowing an average of 31.2 points. In the same span, the Ravens have held a .672 winning percentage against the rest of the NFL while allowing just 19.1 points. The Bills, meanwhile, are 4-1 against Kansas City in the regular season, but 0-4 in the playoffs, including 0-2 on Buffalo’s home field.

After the most recent loss in last season’s AFC championship, a reporter referred to Buffalo as a “city of losers,” a reference to the team’s twisted big-game history that included four consecutive Super Bowl losses in the 1990s. Bills coach Sean McDermott said one of his top goals this season was “changing the narrative on Buffalo,” he told The Buffalo News.

“It bothers me. It honestly pisses me off, because people don’t know this town. They don’t know how hard that is — to get to four straight Super Bowls. It’ll never happen again.”

But will another Bills Super Bowl appearance happen again? Bettors believe so, establishing the Bills and Ravens as the top betting favorites to make it this season, according to DraftKings odds.

Jackson’s and Allen’s credentials are like few others’ in NFL history. Allen’s 76 wins, 262 touchdowns and 30,595 yards are the most in history through the first seven seasons of a quarterback’s career. He won MVP honors last season in part because he had just become the first at his position to finish a season with at least 25 touchdown passes, 10 rushing touchdowns and fewer than 10 interceptions.

Jackson, meanwhile, was setting his own history last season, becoming the first quarterback with 40-plus touchdown passes and fewer than five interceptions — a stat line that reflected his development as a passer since entering the league as a devastating threat to take off and run.

“He’s as good as any passer that there’s ever been,” Ravens coach John Harbaugh said. “And I think now the numbers are proving that.”

Allen and the Bills are 3-2 against Jackson and the Ravens. Last season, the teams traded victories, with the Ravens winning in a resounding rout early in the season only for the Bills to win a narrow divisional-round playoff victory.

“You talk about Lamar, he’s one of the best players to touch the grass, honestly,” Allen said this week. “You can’t give him more opportunities than he needs. You can’t give him short fields.”

Week 1 storylines and matchups

Tampa Bay at Atlanta: Only Kansas City and Buffalo have won more consecutive division titles than the Buccaneers’ four straight. Michael Penix steps into his first full season as Atlanta’s starting quarterback.

Cincinnati at Cleveland: Edge rushers who ended trade requests with new contracts take the spotlight in the Browns’ Myles Garrett and Bengals’ Trey Hendrickson. Hendrickson led the NFL in sacks last season.

Miami at Indianapolis: Dolphins wideout Tyreek Hill averages the most receiving yards in season-opening games in NFL history at 112 yards per game. He’ll need a big game to keep coach Mike McDaniel off the hot seat.

Las Vegas at New England: New coaches Pete Carroll and Mike Vrabel are pinning their hopes on young offensive playmakers. Can Patriots quarterback Drake Maye and Raiders running back Ashton Jeanty deliver from the very start?

Arizona at New Orleans: Saints starting quarterback Spencer Rattler was 0-6 as a rookie, but his team has won six consecutive season openers. Arizona is trying to make the playoffs for just the second time in the last decade.

Pittsburgh at New York Jets: Steelers quarterback Aaron Rodgers, in possibly his final NFL season, faces his former team. In his last four season openers, Rodgers has combined for one touchdown pass and four interceptions.

New York Giants at Washington: The Commanders, under breakout star quarterback Jayden Daniels, is trying to make the playoffs in consecutive seasons for the first time since 1990-92. New York, which threw a league-low 15 touchdown passes last season, brings in new starter Russell Wilson.

Carolina at Jacksonville: Watch how many snaps second overall draft pick Travis Hunter receives on both offense and defense, and whether Panthers quarterback and former No. 1 overall pick Bryce Young can begin this season like he finished the last — on a hot streak.

Tennessee at Denver: Putting its faith in a first-year quarterback Bo Nix paid off for Denver last season. Will it be the same for the Titans and No. 1 overall pick Cam Ward?

San Francisco at Seattle: Will 49ers back Christian McCaffrey be healthy enough to play? Against what is projected to be one of the league’s best defenses, the 49ers’ new $265 million man, Brock Purdy, will need help.

Detroit at Green Bay: After losing both coordinators to new jobs last season, can the Lions maintain their bruising style? And how impactful will new Packers pass rusher Micah Parsons be in his debut since a trade from Dallas?

Houston at Los Angeles Rams: If the Texans, who are breaking in four new starters on the offensive line, can protect quarterback C.J. Stroud, the Texans could be dangerous. Rams quarterback Matthew Stafford is trying to stay untouched, too, after dealing with a back injury all summer.

Minnesota at Chicago (Monday): Bears fans are on edge about how quarterback Caleb Williams will play in his second season, but his first under new coach Ben Johnson. The same could be said about how Vikings fans feel as J.J. McCarthy, their own quarterback from the 2024 draft class, takes over.