Pope Leo XIV urged for humanitarian aid to reach the Gaza Strip and called for an end to the suffering of its people during his first general audience in St. Peter’s Square.

The Vatican reported that approximately 40,000 individuals attended this audience, which followed a significant gathering of around 200,000 people who participated in the inaugural Mass on Sunday, celebrating the first American pope.

Pope Leo, who was formerly Cardinal Robert Prevost from Chicago, commenced the audience by touring the piazza in the popemobile, taking moments to bless numerous babies. In his address, he offered greetings to various groups of pilgrims, speaking in English, Spanish, and the traditional Italian custom of the papacy.

“I renew my heartfelt appeal to allow the entrance of dignified humanitarian aid to Gaza and to put an end to the hostilities whose heartbreaking price is being paid by children, the elderly and sick people,” he said.

Leo did not mention the plight of hostages taken by Hamas during the assault on southern Israel on Oct. 7, 2023, as Pope Francis normally would.

The general audience on Wednesdays is a weekly appointment that popes have kept for decades to allow ordinary faithful to have a face-to-face encounter with the pontiff. It features the pope delivering a brief reflection on a theme or Scripture passage, with summaries provided by others in different languages and the pope directing specific messages to particular faith groups.

The encounter, which lasts more than an hour, usually ends with a brief topical appeal by the pope about a current issue or upcoming event. Leo began it with his now-frequent mantra “Peace be with you.”

To that end, Leo on Tuesday reaffirmed the Vatican’s willingness to host the next round of ceasefire talks between Russia and Ukraine during a phone call with Italian Premier Giorgia Meloni, the Italian leader’s office said.

Meloni made the call after speaking with President Donald Trump and other European leaders, who asked her to verify the Holy See’s offer.

“Finding in the Holy Father the confirmation of the willingness to welcome the next talks between the parties, the premier expressed profound gratitude for Pope Leo XIV’s willingness and his incessant commitment in favor of peace,” Meloni’s office said in a statement late Tuesday.

Trump had referred to the Vatican’s longstanding offer to host talks in reporting on his phone call Monday with Russian President Vladimir Putin.

While low-level talks could take place in Rome, Italy would be hard-pressed to allow Putin to fly into Rome for any higher-level negotiation. Putin is subject to an international arrest warrant against him from the International Criminal Court, of which Italy is a founding member and therefore obliged to execute its warrants.