In a tragic turn of events at Louisville, Kentucky, first responders are scouring the wreckage of a UPS cargo plane that met a fiery end during takeoff from the company’s global aviation hub. The devastating incident on Tuesday evening claimed the lives of at least seven individuals and left 11 others injured, according to local authorities.

The ill-fated aircraft was en route to Honolulu when it crashed around 5:15 p.m. at the UPS Worldport, located at Louisville Muhammad Ali International Airport. The crash resulted in a massive fireball, casting a shadow over one of the busiest air freight hubs in the world.

Kentucky Governor Andy Beshear took to social media on Wednesday morning, sharing the distressing news that 16 families had gathered at a reunification center, anxiously reporting loved ones as unaccounted for in the aftermath of the crash.

Situated just a short drive from downtown Louisville, which borders the Ohio River and the Indiana state line, the airport is surrounded by residential areas, a water park, and several museums. In the immediate chaos following the crash, emergency officials issued a shelter-in-place order extending over a 5-mile radius. By Wednesday morning, this was narrowed to a quarter-mile as authorities kept a close watch on air quality in the vicinity.

Louisville Mayor Craig Greenberg confirmed that more than 200 responders were actively engaged at the crash site as of Tuesday night. “We’ll continue to dedicate every available resource to this effort,” Greenberg assured viewers in an interview with WLKY-TV on Wednesday morning, emphasizing the city’s commitment to the ongoing rescue and recovery operations.

“We’ll continue to put every resource we have available to this, as well,” he told WLKY-TV on Wednesday morning.

Video showed flames on the plane’s left wing and a trail of smoke. The plane then lifted slightly off the ground before crashing and exploding in a huge fireball. Video also revealed portions of a building’s shredded roof next to the end of the runway.

Four of those killed were not on the plane, officials said.

Death toll could rise, Kentucky’s governor says

Beshear said he expects the death toll to increase. Eleven people were also hurt, some of whom had “very significant” injuries, he said.

“Anybody who has seen the images, the video, knows how violent this crash is,” he said.

Beshear said he didn’t know the status of the three crew members aboard the plane, a McDonnell Douglas MD-11 made in 1991.

UPS’s largest package handling facility is in Louisville and the company announced Tuesday night that it had halted package sorting at the center and didn’t say when it would resume. The hub employs thousands of workers, has 300 daily flights and sorts more than 400,000 packages an hour.

“We all know somebody who works at UPS,” Louisville Metro Council member Betsy Ruhe said. “And they’re all texting their friends, their family, trying to make sure everyone is safe. Sadly, some of those texts are probably going to go unanswered.”

Greenberg said the National Transportation Safety Board is handling the investigation and sending 28 people. He said city emergency management officials put together a form where nearby residents can report debris in their yards.

Airport is resuming operations after being shut down

The airport, meanwhile, shut down for the night. It resumed operations Wednesday morning, with at least one runway open. Flights that were canceled Tuesday were scheduled to depart and arrive first. Some flights previously scheduled to take off from the airport Wednesday morning were canceled.

Some stranded passengers spent the night in the airport.

Some roads near the airport remained closed Wednesday and a public school district in Louisville canceled classes and activities for the day.

Pablo Rojas, an aviation attorney, said that based on the videos it looked like the aircraft was struggling to gain altitude as a fire blazed on its left side around one of its engines. Given the large amount of fuel it was carrying, once the fire started in that area, it would’ve been only a matter of time before there was an explosion or the fire grew rapidly.

“Really the plane itself is almost acting like a bomb because of the amount of fuel,” he said.

The governor said a business, Kentucky Petroleum Recycling, appeared to be “hit pretty directly,” and a nearby auto parts operation was also affected.

People gather seeking information about missing loved ones

Eric Richardson stood outside a police training academy where people gathered looking for information about missing loved ones Tuesday night, hoping to find out what had happened to his girlfriend. She had been at a metal recycling business near the explosion and wasn’t answering her phone, he told The Associated Press. Her phone’s live location said she was still there.

Bobby Whelan, Richardson’s friend, had been in front of her in line, but had left minutes before the explosion. He said he was about a quarter mile down the road when he heard what sounded like a bomb exploding.

“We don’t even want to think about anything but the best,” Whelan said. “All our friends were there.”

Tom Brooks Jr., who runs a metal recycling business down the street, said the unbelievable magnitude of the crash “just rocked the whole place.”

“This was massive. I mean, it literally looked like a war zone,” he said.

Destyn Mitchell was working as a host at an Outback restaurant, about a 15-minute drive from the crash, when she heard a loud boom.

“People who just sat down to eat got up and left in under 30 minutes and packed up their food because they wanted to hurry up and get home,” she said.