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It’s the first new class of treatment for major depression in more than three decades.

Alexis Hutcheon, 31, says the spray, called Spravato, has made a huge difference to how she tackles her dark days.

The nasal spray being used to help treat depression. (Nine)

“It’s like a weight lifted off,” she said.

“I feel more well than I ever have.”

She had tried different anti-depressants, but experts say this one works differently from traditional treatments.

“It acts on a different neurotransmitter in the brain,” Associate Professor Elizabeth Scott Principal Researcher, Brain and Mind Centre at the University of Sydney, said.

“We think what happens is it increases the connectivity between the synapses the connections between your brain cells, it actually makes them fire better.”

Professor Ian Hickie from the Centre, said the drug has a dramatic effect for at least half of the people who use it.

“So, to get 50 per cent of those people back to school, back to work, engaged with life is a major achievement, it’s a step forward,” he said.

It took three years for the add-on therapy, also known as esketamine, to be approved in Australia.

However, it costs several thousand dollars for a course.

Now, for the second time, a submission for subsidy is before a government advisory committee.

Hickie said he believed people with mental health problems are unfairly treated when it comes to funding.

“It’s my view that people with mental health problems, major depression, schizophrenia, have not been treated fairly not been treated equitably compared to people with breast cancer, compared to people with arthritis,” he said.

The Pharmaceutical Benefits Advisory Committee is currently collecting submissions online from patients, carers and experts, as part of a review of all the evidence for reimbursed access.

6. Uruguay

The most triple vaccinated countries on Earth

Comments close next week, with a decision expected at a meeting in July.

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