Carrie Anne Fleming, widely recognized for her portrayal in the fantasy series Supernatural, has passed away at the age of 51.

Jim Beaver, her co-star from Supernatural, who is 75 years old, confirmed to Variety on Sunday that her death was due to complications related to breast cancer.

The actress breathed her last on February 26 in Sidney, British Columbia, in her homeland of Canada.

Fleming leaves behind her daughter, Madalyn Rose. Plans for a memorial service will be shared at a later time.

On Supernatural, Fleming brought to life the character of Karen Singer, the spouse of Bobby Singer, portrayed by Beaver, who was a crucial supporter of the Winchester siblings.

In a heartfelt tribute on Facebook, Beaver described Fleming as his ‘soul mate,’ mentioning that despite being separated by distance, their love remained strong.

Carrie Anne Fleming, best known for her role on the fantasy drama Supernatural, has died at 51; She is pictured in 2014

The actress died from breast cancer complications, according to Variety; Seen as Karen Singer in Supernatural

‘To find a soul mate once in life is something of a miracle. To find one twice is almost unimaginable. To love and be loved is a pearl above price, but such pearls do come more than once or twice to the lucky,’ he wrote in a lengthy post.

‘But to find oneself paired with someone who not only loves and is loved, but who seems by magic or the grace of the gods to understand you, to want what you are, to want you to be what you are, who GETS you and never feels the need to have you defend who you are, and about whom you feel the same – how many of us can say that spark of divinity has alighted on us once, much less twice? I can.’

Beaver went on: ‘To find a soul mate once in life and lose her is unmitigated pain. To find one twice and lose them both is something that words cannot shape. Few who know me do not know about my first, my Cecily, my first and greatest love, the mother of my child, and how Cecily’s young death came near to destroying me. Far fewer know that I found something akin to that again some years after Cecily’s death.’

‘Carrie Anne Fleming was cast as my wife on Supernatural in my fifth season on the show. I fell for her hard, and I did it mere seconds after meeting her. To my joy and shock, it seems the same thing happened to her,’ the actor wrote. 

‘We “met cute,” in Hollywood speak. As we sat on the set before our first scene, saying our hellos and breaking the ice as actors do when first paired up for a scene, she mentioned the name Madeline Rose. I was flummoxed, because that is my daughter’s name, and there was no reason Carrie should know it. I said tentatively, “Who’s Madeline Rose?” She said, “Oh, that’s my daughter.” I said, “Wait. That’s MY daughter.”‘

He said that was ‘the beginning of a beautiful friendship.’ 

‘We ran lines of dialog together in my trailer and talked for hours that first day, and the electricity between us was practically visible,’ he wrote.

Beaver called Fleming ‘a powerhouse of vitality and goodwill and amazingly good nature, with a rapturous laugh and an utterly adorable personality that didn’t seem to have an off switch. I was so in love I think my eyes turned silver. She seemed to think I was worth hanging around with, too.’ 

Her Supernatural co-star Jim Beaver confirmed her death on Sunday; The two are seen in a 2010 still from the show

Beaver called Fleming his ‘soul mate’ in a poignant tribute on Facebook, and said that though distance kept them apart, they ‘loved each other’

‘I fell for her hard, and I did it mere seconds after meeting her. To my joy and shock, it seems the same thing happened to her,’ the actor wrote

The actor shared a number of touching photos featuring him and Fleming

‘We shot Supernatural in Canada, where she lived. I live in Southern California. The geographic and legal ramifications of those facts, particularly as pertains to child custody, kept us both physically and matrimonially apart, though we remedied the first when we could and, I’m sure, at some point we would have remedied the latter if it had been possible.’

‘As it was, we just loved each other as best we could. There were others, for both of us, but always there was the bond we had started with. Had certain laws and maps been different, I’m not sure I would have been able to love anyone else.’

‘She got me like only one other person really, truly ever has. Except for my love for her, I’m not sure if I would have been good for her. But she was terribly good for me.’

‘I lost Cecily to cancer in 2004. Thursday, I lost Carrie to the same disease. I never thought my heart could break so badly more than once. But it has. But, oh, the two torches I carry – what bright, bright light they shed.’

Fleming’s other notable roles include iZombie, Smallville, Good Luck Chuck, The L Word, Married Life and Supergirl. 

Born on August 16, 1974, in Digby, Nova Scotia, Fleming attended Mount Douglas Senior Secondary in Victoria, British Columbia, and studied drama at the Kaleidoscope Theatre as well as the Kidco Theatre Dance Company. 

Her early roles included an uncredited appearance in Adam Sandler’s Happy Gilmore, as well as a role in Viper.

In 2005 she was cast in Dario Argento’s show Masters of Horror, where she starred as a disfigured woman with cannibalistic urges.

She went on to star in other horror shows, including Bloodsuckers and The Tooth Fairy.

She came to prominence after landing a guest role on Supernatural, which ran for 15 seasons from 2005 to 2020.

The series starred Jared Padalecki as Sam Winchester and Jensen Ackles as his brother Dean Winchester. The brothers — whose father John Winchester was played by Jeffrey Dean Morgan — hunted supernatural creatures across the country.

Fleming’s other notable roles include iZombie, Smallville, Good Luck Chuck, The L Word, Married Life and Supergirl; Seen in a still from iZombie

Following their father’s death, Bobby became a surrogate father figure for Sam and Dean, and they later learned about his tragic past, including the loss of his wife Karen, who had been possessed by a demon. After her death, Karen continued to appear in flashbacks. 

Fleming went on to play Candy Baker on five seasons of the CW’s iZombie.

She also appeared in the 2015 TV film The Unauthorized Full House Story, which explored the behind-the-scenes making of the hit sitcom.

Fleming played the mother of Full House star Candace Cameron Bure, who portrayed D.J. Tanner on the show.

Fleming also performed in a number of British Columbia stage productions, including Steel Magnolias, Noises Off, and Romeo and Juliet.