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Parts of the area could see as much as eight inches of snowfall accumulation.
The National Weather Service has issued a Winter Storm Warning in effect for central and northern Cook County until noon Friday.
A Winter Weather Advisory is in effect for southern Cook, DuPage and Will counties and Lake County in Indiana until 10 a.m. Friday.
ABC7 Meteorologist Tracy Butler said the worst of the snow will fall during the morning rush and will diminish in the afternoon.
Heavy snow creates hazardous road conditions
Areas under the Winter Storm Warning could receive 4-8 inches of snow and potentially more if a snow band were to set up for a prolonged period of time.
Areas under the Winter Weather Advisory are forecast to receive about 1-4 inches of snow.
MORE: ABC7 AccuWeather 7-day Forecast
Snowfall rates of 1 to 2 inches per hour are possible and could reduce visibilities to less than half a mile and lead to fast accumulations on roadways, ABC7 Meteorologist Larry Mowry said.
Drivers should plan for hazardous road conditions during the Friday morning commute. Lake effect snow is likely to affect the Dan Ryan Expressway, Bishop Ford Freeway, the Skyway, I-80 and the highways in Lake County, Indiana.
The Chicago Department of Streets and Sanitation has deployed approximately 270 snow vehicles to respond to the snowstorm. Crews will focus on the city’s main arterial streets before shifting to residential side streets.
Early Friday morning, snow-covered roads led to several crashes on Chicago area expressways.
On The Dan Ryan Expressway, there was a three-car spinout crash. At 71st Street and Cottage Grove Avenue, a two-car pin-in crash left two people injured.
At Chicago’s airports, 26 flights were canceled at O’Hare and 29 flights were canceled at Midway as of 4:56 a.m.
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