In an emotional new video, Savannah Guthrie pleaded for captors to provide evidence that her missing mother, Nancy, is still alive.

The 84-year-old Nancy disappeared on Saturday night after being dropped off at a vast property in Arizona by her Italian son-in-law, Tommaso Cioni, who was the last person to see her.

In a heartfelt message shared on Instagram Wednesday evening, the Today Show host paid tribute to her mother alongside her siblings.

Guthrie expressed gratitude for the prayers and support received and shared details about her ‘beloved mom’ Nancy’s condition.

“She is 84 years old, with fragile health and heart. She lives in constant pain and is without the medicine she needs to endure and survive,” Guthrie explained.

Flanked by her sister Annie and brother Camron, Guthrie then made a direct appeal to those who might be holding their mother.

‘We too have heard the reports about a ransom letter in the media. As a family, we are doing everything that we can,’ Guthrie said. 

Guthrie then said to the potential kidnappers that ‘we are ready to talk’ but wanted proof that they weren’t potentially using fraudulent images of her. 

‘We live in a world where voices and images and images are easily manipulated. We need to know, without a doubt, that she is alive and that you have her. We want to hear from you and we are ready to listen. Please, reach out to us,’ she said, holding back tears.

Guthrie then attempted to speak to her 84-year-old mother. 

‘Mommy, if you are hearing this, you are a strong woman. You are God’s precious daughter, Nancy.’

‘We believe and know that even in this valley, he is with you. Everyone is looking for you, mommy, everywhere. We will not rest, your children will not rest until we are together again. 

‘We speak to you every moment and we pray without ceasing and we rejoice in advance for the day that we hold you in our arms again. We love you, mom.’

Annie and Camron Guthrie then echo their sister’s words: ‘We love you, mom. Stay strong.’ 

The video was simply captioned: ‘Bring her home.’ 

Donald Trump confirmed he spoke with Guthrie and had heard her pleas in a Truth Social post shortly after the video went live.

‘I spoke with Savannah Guthrie, and let her know that I am directing ALL Federal Law Enforcement to be at the family’s, and Local Law Enforcement’s, complete disposal, IMMEDIATELY. We are deploying all resources to get her mother home safely. The prayers of our Nation are with her and her family. GOD BLESS AND PROTECT NANCY!’ 

Cops said on Tuesday that they had turned the $1 million adobe-style house back over to the Guthrie family, but the FBI had descended Wednesday.

Police have previously been investigating the possibility that a ransom demand has been made. 

CNN legal analyst Andrew McCabe said in response to the video that it appeared unclear whether the Guthries had a legitimate offer.

‘I feel like this is a fairly strong signal that they do NOT believe that they’ve had a legitimate ransom demand yet… This, to me, reads like an effort to establish a line of communication,’ he said. 

The FBI descended on the Tucson home on Wednesday as law enforcement efforts were stepped up dramatically in the search for the missing retiree.

A pickup truck from the Pima County Sherriff’s Department arrived at Nancy’s home,  along with two carloads of FBI investigators. The house has since been taped off, and agents were still inside as of 5.30pm local time.

K-9 units were also spotted combing the inside, according to Fox News.

Meanwhile, a second pair of investigators were at the home of Savannah Guthrie’s sister Annie. The detectives were seen collecting what looked like a tripod and lights from their car before going back inside.

Officers were previously spotted at the house, where the Today Show anchor is believed to be holed up, on Tuesday. 

Wednesday’s visit came shortly after a detective from an online pedophile unit showed up to talk to the Guthrie family.

Seen outside the house in Daily Mail photos, the man was wearing a t-shirt emblazoned with the Internet Crimes Against Children Task Force badge.

The FBI affiliate specializes in combating online grooming and technology enabled child abuse. 

The uptick in activity comes shortly after a source told a local ABC News affiliate that the FBI is rushing in outside experts – including hostage negotiation specialists.

Until Tuesday, the case had been handled entirely by the Pima County Sheriff’s Department who called in extra help after realizing the devout grandmother had been abducted.

Signs of a struggle can still be seen at her home, with her Ring doorbell removed and a splatter of blood by the entrance door.

The 84-year-old mother-of-three lives alone at the house in the affluent Catalina Foothills neighborhood, where authorities found her phone, wallet and car following her mysterious disappearance on January 31.

An Apple Watch was also found inside the property, which investigators say stopped syncing with her pacemaker at around 2am – suggesting she was taken from her home at around that time.

Officers are now looking into Savannah’s superfans who have piled her with gifts and mail before her mother was abducted, the Daily Mail revealed earlier on Wednesday.

Investigators specifically asked NBC whether there were any troubling fan interactions that could be relevant to the case, a senior source claimed.

No suspect has been identified and police insist there is no danger to the wider public. 

However, investigators have not ruled out that Nancy may have been targeted because she is the mother of the famous Today show host.

At the same time, though, the Pima County Sheriff’s Department is looking into the possibility that Nancy’s kidnapping may be linked to a trespassing case in January, TMZ reports.  

In that case, one of her neighbors told authorities he noticed a suspicious person outside of his own home. 

But when the unidentified lurker triggered a motion sensor, causing floodlights to switch on, he fled the scene and witnesses were unable to provide a description of the suspect.

Police are now going door-to-door collecting security camera footage from neighbors as they attempt to identify a suspect and are searching for a vehicle of interest, a law enforcement source said.

They are also investigating the possibility that a ransom demand has been made.

Despite the lack of answers, Pima County Sheriff Chris Nanos has faith that Nancy is still alive.

‘We have nothing else to go on but the belief that she is here,’ he said in an interview with NBC’s Liz Kreutz. ‘She’s present. She’s alive, and we want to save her.’

He noted that his department is taking all tips and leads very seriously.

‘The leads we’ve got coming in are critical to us. They’re valuable, and we’re sharing those with the FBI and others,’ Nanos said.

To aid in the investigation, President Donald Trump announced he was allocating additional federal support for the search.

He said on Tuesday he planned to call Savannah, noting that his thoughts were with the news anchor amid the ‘terrible’ situation.

‘I’m going to call her later on, I think it’s a terrible thing,’ Trump said. ‘Very unusual situation, but we’re going to find out.’

Then, on Wednesday, the president made good on his promise, NBC News anchor Tom Llamas reported on air.

He said that Trump took the moment to ‘offer words of support for her and her family as they search for her mother.’

Authorities are expected to provide another update into the investigation on Thursday. 

Guthrie’s upscale Arizona neighborhood is quiet and mostly dark at night, lit mainly by car headlights and homes spaced far apart. 

Long driveways, front gates and desert plants provide a buffer from the winding streets and curious eyes.

Saguaro cacti tower above the roofline of Guthrie’s Tucson-area home, and wispy trees partially block the view of the front door.

Those are the conditions that investigators are faced with as they try to piece together the moments before and immediately after the disappearance of Guthrie. Authorities offered no detailed update Wednesday.

‘Is there somebody out there who´s kidnapping elderly people in the middle of the night, every night?’ Pima County Sheriff Chris Nanos said Tuesday. 

‘We don´t believe that´s the case. We believe Nancy was taken from her home against her will.’

The sheriff suggested there was video from some cameras, though he didn´t elaborate, adding: ‘That´s all been submitted and we´re doing our best with the companies that own those cameras or built those cameras.’

Nanos’ office said Wednesday that detectives still were speaking with anyone who had contact with Nancy Guthrie last weekend but that no suspect or person of interest had been identified. 

This is a developing story.