Eric Dane’s recent guest role on the series “Brilliant Minds” carried a particularly emotional weight, as he stepped into the shoes of a courageous firefighter grappling with ALS, mirroring his real-life battle with the same degenerative disease.

During Monday’s episode, the 53-year-old “Grey’s Anatomy” veteran, who publicly disclosed his diagnosis in April, took on the character of Matthew—a seasoned firefighter facing the challenge of disclosing his ALS condition to his grown daughter and former wife.

Viewers were moved to tears by the “heartbreaking” narrative, with many praising Dane for his “powerful” and “touching” portrayal of Matthew’s journey.

As the episode unfolded, Matthew’s condition visibly deteriorated. Dr. Oliver Wolf, played by Zachary Quinto, encouraged him to rely on his family and friends for support. However, Matthew resisted, contemplating skipping Thanksgiving to spare his loved ones further worry.

Matthew also hesitated to embrace a voice-banking application, struggling to confront a future where he might lose the ability to speak.

The episode concluded with a deeply moving scene where Matthew records a heartfelt message on the voice app. This poignant moment resonated deeply, earning Dane a ten-minute standing ovation from the crew, as noted by “Brilliant Minds” showrunner Michael Grassi.

Eric Dane’s, 53, guest appearance on Brilliant Minds proved especially poignant as he portrayed a firefighter battling ALS amid his own struggle with the degenerative condition

On Monday’s episode, Dane — who first revealed his devastating diagnosis in April — played Matthew, a veteran firefighter wrestling with how to reveal the diagnosis to his family

After further sessions with Wolf and the interns, Matthew began to open up. 

He discussed his ALS with loved ones over Thanksgiving dinner and received a heartfelt tribute from his New York Fire Department family.

After the episode many fans took to social media, with one writing, ‘Eric Dane is breaking my heart.’

‘Crying with eric dane in this series,’ another added.

Another fan praised him for doing a ‘Beautiful job.’

Marking his return to the medical drama world, Dane teamed up with Grassi to craft an episode showing what it’s like for families to face a difficult ALS diagnosis.

‘There’s no right or wrong way, there’s no rulebook on how to do it,’ Grassi told NBC Insider.

‘And, for the Thanksgiving episode, we just thought it would be interesting to see a family work through something that’s not easy.’

Fans were left in ‘tears’ after the ‘heartbreaking’ episode aired, with many calling Dane’s portrayal ‘powerful’ and ‘touching’

As Matthew’s breathing worsened, Dr. Oliver Wolf (Zachary Quinto) suggested that he should lean on his support system, but Matthew was against the idea

He also resisted the idea of using a voice-banking app, struggling to imagine a future in which he couldn’t speak

After further sessions with Wolf and the interns, Matthew began to open up

He discussed his ALS with loved ones over Thanksgiving dinner and received a heartfelt tribute from his New York Fire Department family

The scene that closed out the episode — Matthew’s heart-wrenching message he ended up recording on the voice app — earned the actor a 10 minute standing ovation from the crew, according to Brilliant Minds showrunner Michael Grassi

After the episode many fans took to social media, with one writing, ‘Eric Dane is breaking my heart’

‘We love this idea of somebody who is a firefighter who has dedicated his entire life to helping others and in service, and that’s who he is, that’s his whole sense of self.’

‘And then to have to, later in life, accept help after helping people your entire life, is not easy for somebody like Matthew… It’s not a new thing that Matthew is not letting people in; it’s been a lifelong struggle of his to let people help him. He’s stubborn, and I love that about his character.’

Breaking from tradition, the episode closed not with Wolf’s usual monologue but with Matthew’s heart-wrenching message.

Matthew said: ‘The act of rescue is often linked to things like heroism and bravery, but for guys like me, I’ve always looked at it as an act of caring. I guess I never thought of myself as the one who needed to be cared for. But I know now that even on my hardest of days, you and your mom will be there to save me from any fires that may come our way.’

‘Sometimes the most heroic thing you can do is not running into a burning building. Sometimes, it’s quieter, smaller, and in a way even harder, at least for me,’ he continued, sharing that accepting help from his daughter and mom was one of the biggest challenges.

‘For me, this is the bravest thing I’ve ever done, and it’s scary as hell,’ he concluded tearfully. ‘But it is worth it if it means more time with you.’

Grassi told NBC Insider, ‘That scene was so moving, and Eric’s performance in it was so vulnerable and so beautiful.’

‘After we called cut on that scene and wrapped that scene, the entire crew stood up and clapped Matthew out that day for about 10 minutes. They were just so moved by his incredible performance, and so that was a really special day.’

ALS, also known as Lou Gehrig’s disease, is a rare and incurable motor neuron disorder that affects around 5,000 Americans each year

Eric gained fame as Grey’s Anatomy’s Dr Mark Sloan 

As well as his appearance on the NBC show, he is ploughing ahead with a third season of Euphoria.

In October, Dane appeared to struggle while speaking to a photographer at the Washington, DC airport, after he was asked, ‘What would you say to your fans who are hoping everything is okay?’

Dane replied softly, ‘Keep the faith, man.’

According to sources close to the actor, the beloved star has been grappling with his own mortality.

One insider told the Daily Mail: ‘Nobody wants to think about or address their own mortality, but that is exactly what Eric is going through now.

‘He knows his fate and is trying to figure out how he wants to enjoy life, how to be a beacon of hope and help others who are struggling themselves. He also wants to enjoy being with family and friends and actually take this time to live.’

ALS, also known as Lou Gehrig’s disease, is a rare and incurable motor neuron disorder that affects around 5,000 Americans each year.

Symptoms often progress rapidly and are difficult to detect in the early stages.

Dane first noticed weakness in his right hand in early 2024, assuming he’d simply ‘been texting too much or my hand was fatigued’.

After months of testing and multiple specialist visits, he received the official diagnosis in April.

By June, he had lost use of his right arm.

While life expectancy for ALS patients typically ranges from three to five years, Dane’s decline has been swift and painful. 

Dane’s ALS announcement came shortly after the star and his estranged wife, actress Rebecca Gayheart , 54, decided to call off their divorce after seven years apart; pictured in June 2017 with their daughters Bille and Georgia

Through it all, his ex-wife and longtime confidante, Beverly Hills, 90210 actress Rebecca Gayheart, has remained one of his strongest sources of support.

The couple’s story began in 2003 when Gayheart, then fresh from a long-term relationship with producer Brett Ratner and starring in Nip/Tuck, met Dane, who was still climbing the Hollywood ladder after small roles in Saved by the Bell, The Wonder Years, and Roseanne.

They shares two daughters, Billie, 15, and Georgia, 13. 

By 2018, his marriage to Gayheart had run its course, and she filed for divorce after 14 years together.

When Dane received his ALS diagnosis, Gayheart reportedly halted the divorce process and recommitted to being by his side.

‘We are best of friends. We are really close. We are great co-parents,’ she told E! on the eve of his announcement. ‘We really figured out the formula to staying a family… I think our kids are benefiting greatly from it and we are as well.’