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Illinois State Police said they responded just before 4:30 a.m. to a report of an injured pedestrian on eastbound Interstate 290 near Laramie Avenue.
The pedestrian suffered life threatening injuries and died, state police said.
The eastbound lanes of I-290 near Laramie are closed for the investigation, and traffic is being diverted to Central Avenue.
A red car could be seen near the incident with its windshield shattered, and a shoe was lying in the roadway, as well.
An emergency traffic patroller on the scene later Sunday morning said it was possible a semitrailer hit the individual, but police did not immediately provide additional information about the vehicle involved.
Anyone who witnessed the incident or has any knowledge of the incident is asked to call the ISP at 847-294-4400. Witnesses can remain anonymous.
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