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Knives and a machete were used, and six were taken to hospital.
Officers were called to the Nairobi Lounge on Grenfell Street after reports of a brawl just after 1am.
One man had his life saved at the scene.
Paramedics were worked on the 24-year old man who had been stabbed multiple times.
In footage, people can be seen fleeing the bar moments before police patrols arrived
South Australia Police Chief Inspector Matt Nairn called what happened “very concerning”.
“We can identify the people involved are people of African descent, this is an African type of nightclub, involved in the incident,” he said.
Two men, aged 18 and 22, have been arrested.
The investigation involves officers from Police Taskforce Meld, which was set up to combat youth crime in Adelaide.
Nairobi Lounge operators told 9News they believed trouble makers had come from outside and targeted a private event being held at the venue.
They condemned the violence and said security measures such as metal detectors had been introduced to precent it.