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Police allege several victims were “stabbed or assaulted” with weapons just after 1am today inside a bar on Grenfell Street.
Officers were called to the hotel after reports of a brawl.
A 24-year-old man from Devon Park was taken to the Royal Adelaide Hospital in a serious but stable condition.
An 18-year-old Munno Para West man has been charged with affray and disorderly behaviour and a 22-year-old Paralowie man has been charged with disorderly behaviour, as well as refusal to state his name and address.
Police said enquiries regarding the incident remain ongoing.