Over 100 firefighters are actively fighting a massive fire that led several high-rise buildings to catch fire in the heart of Baltimore on Tuesday afternoon.

Officials from the Baltimore City Fire Department (BCFD) confirmed that the five-alarm fire is located downtown near North Howard and West Fayette streets. Firefighting teams were still working to control the fire as of 4:40 p.m.

According to officials, one building has collapsed, and two additional four-story buildings caught fire. These three buildings are thought to have been vacant, but firefighters have not entered the premises due to their instability.

Firefighters responded to a massive fire Tuesday in downtown Baltimore. (WBFF)

Nearby landmarks include the Hippodrome Theatre, CFG Bank Arena, and the University of Maryland’s Baltimore campus.

Baltimore Fire did not immediately respond to inquiries from Fox News Digital.