In an important development concerning the disappearance of Nancy Guthrie, Pima County Sheriff Chris Nanos has officially confirmed that her family is not involved in the case. This declaration aims to dispel any lingering doubts surrounding the role of Guthrie’s relatives in the investigation.

“Let me make it perfectly clear,” Sheriff Nanos stated on Monday afternoon, “the Guthrie family—including all siblings and their spouses—has been thoroughly cleared of any involvement in this matter. From the beginning, they have shown nothing but cooperation and grace, and they too are victims here.”

He further emphasized, “To accuse them otherwise is not just incorrect, but it is also deeply hurtful. The Guthrie family deserves our empathy and respect. I urge the media to uphold their responsibility by reporting with compassion and professionalism.”

The Guthrie siblings, including Savannah, Annie, and Camron, recently turned to social media with a heartfelt plea for information regarding their mother’s disappearance. On February 4, 2025, they posted an emotional message on Instagram, urging anyone with details to step forward. (Credit: Instagram/@SavannahGuthrie/Today)

In an interview with Fox News, Sheriff Nanos disclosed that DNA found at the scene did not match any family members or individuals closely associated with Nancy Guthrie. This revelation follows rampant online speculation suggesting potential family involvement.

The announcement comes after intense online speculation that a family member might have been involved. 

Monday marked the beginning of the third week of the investigation, which has yielded little in the way of answers about the family matriarch’s whereabouts. 

However, there are five key pieces of evidence that investigators have discussed as Monday. 

The first is a dramatic doorbell camera video released by the FBI showing a masked suspect approaching Guthrie’s front door in the dead of night. According to FBI analysts, the suspect is between 5 feet, 9 inches tall and 5 feet, 10 inches tall and has an average build. He was wearing a black Ozark Trail brand backpack, sold at Walmart.

The second is a DNA sample that came from an unknown individual inside Guthrie’s home. 

Photos released on Feb. 10, 2025, show a “subject” on Nancy Guthrie’s property.  (Provided by FBI)

The FBI is checking the DNA against a glove recovered from inside a two-mile search radius around the house, and said it “appears to match the gloves of the subject in the surveillance video.” Federal law enforcement also said the glove contained DNA consistent with an “unknown male profile.” 

The DNA profile is expected to be run through CODIS in the near future. 

The third is blood that is a genetic match to Guthrie’s, which was found on her front porch. It remains unclear when the blood was spilled.

Authorities also know that Guthrie’s pacemaker lost connection to the phone application it was tethered to at 2:28 a.m. on Sunday, Feb. 1. They used a high-tech Bluetooth scanning device, placed in a low-flying helicopter, to try to detect the pacemaker. That was unsuccessful. 

FBI investigators canvass the neighborhood around Annie Guthrie’s home in Tucson, Arizona, Tuesday, February 10, 2026. The investigations into the disappearance of her mother, Nancy Guthrie continues.  (DWS for Fox News Digital)

Nancy Guthrie disappearance timeline: 
Jan. 31, 2026
• Between 9:30–9:45 p.m. – Family drops Nancy off at home
• 9:50 p.m. – Garage door closes (per authorities)
Feb. 1, 2026
• 1:47 a.m. – Doorbell camera disconnects
• 2:12 a.m. – Security camera detects motion
• 2:28 a.m. – Pacemaker disconnects from phone application
• 11:56 a.m. – Family checks on Nancy after she misses weekly church livestream gathering
• 12:03 p.m. — 911 called
• 12:15 p.m. — Sheriff’s deputies arrive at home