In a groundbreaking move, President Donald Trump has signed an executive order that reclassifies illicit fentanyl and its precursor chemicals as Weapons of Mass Destruction (WMD). The President emphasized that the danger posed by fentanyl is more in line with that of a chemical weapon rather than a conventional drug.

“Today marks a pivotal step in safeguarding Americans from the devastating flow of deadly fentanyl into our nation,” Trump announced from the Oval Office on Monday. “With the executive order I’m enacting today, we are officially labeling fentanyl as a weapon of mass destruction — because it truly is one.”

The order stipulates that illicit fentanyl bears a closer resemblance to a chemical weapon than to a narcotic. Highlighting its lethal potential, it notes that as little as two milligrams—”an almost invisible amount, akin to 10 to 15 grains of table salt”—can be fatal. The document points out that fentanyl overdoses have claimed hundreds of thousands of American lives, arguing that its manufacture and distribution by criminal syndicates now represent a grave national security menace.

Furthermore, the order describes how cartel networks, which are responsible for the influx of fentanyl into the U.S., are fueling “lawlessness” across the Western Hemisphere. These operations are said to finance activities such as assassinations, terrorism, and insurgencies globally.

The document also underscores that the two leading cartels engaged in fentanyl trafficking are embroiled in armed territorial conflicts, spreading violence that surpasses the drug crisis alone. It warns about the potential for fentanyl to be used in “large-scale terror attacks” by malicious entities, which is a key reason for invoking WMD regulations.

“As President of the United States, my foremost obligation is the protection of the nation and its people,” the order declares. “Therefore, I am designating illicit fentanyl and its primary precursor chemicals as Weapons of Mass Destruction.”

US President Donald Trump signs an executive order during a Mexican Border Defense medal presentation in the Oval Office of the White House in Washington, DC, US, on Monday, Dec. 15, 2025. Trump said he was classifying fentanyl as a “weapon of mass destruction” in his latest push to ratchet up pressure on Latin America over drug trafficking. (Bonnie Cash/UPI/Bloomberg via Getty Images)

The directive outlines a broad interagency strategy to confront fentanyl trafficking using tools typically reserved for nuclear, chemical, and biological threats. It instructs the Justice Department, State Department, Treasury Department, the Department of War, and the Department of Homeland Security to take “appropriate action” to eliminate the threat posed by illicit fentanyl and its precursor chemicals.

Under Section 2, the order requires the Justice Department to immediately intensify investigations and prosecutions. State and Treasury must target traffickers with sanctions and financial penalties, while the Departments of War and Justice will determine whether military resources should support enforcement efforts. 

The Pentagon and Homeland Security are directed to update domestic chemical-incident response plans to include fentanyl, and Homeland Security must use WMD-related intelligence to identify smuggling networks and strengthen counter-fentanyl operations.

President Donald Trump speaks during a bill signing ceremony in the East Room of the White House in Washington, DC, on Wednesday, July 16, 2025. Trump signed legislation that strengthens criminal penalties for fentanyl, hailing it as a historic step toward justice in his latest effort to address the public health crisis spurred by the deadly drug.  (Al Drago/Bloomberg via Getty Images)

The order concludes with definitions of “illicit fentanyl” and “core precursor chemicals,” and includes standard provisions noting that implementation must comply with existing law, creates no new legal rights, and will be carried out using available appropriations. The Justice Department will cover the cost of publication as part of the order’s implementation.

“This is yet another action in President Trump’s crackdown on fentanyl — on behalf of every American who has lost a loved one to this deadly poison,” White House Press Secretary Karoline Leavitt wrote in a post on X.

Officials say the WMD designation will enable more aggressive investigations, deeper interagency coordination, and heightened international pressure on cartels and their financial backers, marking one of the most significant escalations in the federal government’s approach to the fentanyl crisis.

“No bomb does what this is doing,” Trump said. “We’re losing 200,000 to 300,000 people every year that we know of. So we’re officially designating fentanyl as a weapon of mass destruction.”

Stepheny Price covers crime, including missing persons, homicides and migrant crime. Send story tips to stepheny.price@fox.com.