Just hours after Israel launched attacks on Iran’s nuclear and military sites, Israeli Prime Minister Benjamin Netanyahu reached out directly to the Iranian populace, urging: “This is your chance to oppose the regime.”

The regime’s position internationally is shaky, given its strong backing of state-sponsored terrorism that has affected neighboring countries from Syria and Yemen to Bahrain and Saudi Arabia. Along with years of domestic turmoil, this could indicate that regime change might be on the horizon.

“We are engaged in one of the most significant military operations in history,” Netanyahu stated on Friday. “The Islamic regime, which has oppressed you for nearly five decades, poses a threat to obliterate our nation.”

In this image made from a video released by the Israeli Government Press Office, Prime Minister Benjamin Netanyahu gives a statement Tuesday, March 18, 2025, in Tel Aviv, Israel. (Israeli Government Press Office via AP)

Amini’s death sparked mass protests across the country, which Iran brutally clapped back at and continues to execute those arrested during the demonstrations. 

Fox News Digital was told by Yigal Carmon, President of the Middle East Media Research Institute (MEMRI), that members of the Ahwazis, a minority group in south-western Iran, which make up 6-8% of the population, have already been arrested by the regime amid its fears another internal rebellion could brew alongside war with Israel.

It is unclear if any demonstrations have yet begun or if their arrests were pre-emptively carried out. 

“A regime change will be supported by many,” Carmon said. “The fact is that only the minorities can bring a regime change because they are militarily organized.”

“A coalition of non-Persian ethnic groups could topple the regime in a few months,” he said. “Unlike the Persian anti-regime population, the non-Persian anti-regime population is militarily organized.”

People light a fire during a protest over the death of Mahsa Amini, a woman who died after being arrested by the Islamic Republic’s “morality police”, in Tehran, Iran, on Sept. 21, 2022. (West Asia News Agency)

Other minority groups, like the Kurds, who make up 10%-15% of Iran’s population and who live primarily in the northwestern border areas near Iraq and Turkey, as well as the Baloch people, who encompass another 5% of the population and live along Iran’s southeast border with Pakistan, also have a long history of opposing the regime, though they have also suffered brutal consequences. 

“It has never been weaker. This is your opportunity to stand up and let your voices be heard. Woman, Life, Freedom Zan, Zendegi, Azadi,” Netanyahu said.  “As I said yesterday and many times before, Israel’s fight is not against the Iranian people. 

“Our fight is against the murderous Islamic regime that oppresses and impoverishes you,” he added.