I have been involved in entrepreneurship long enough to recognize when a major trend is emerging. I want to point out that biohacking is not just another short-lived wellness trend; it is a powerful business approach that is providing savvy entrepreneurs with a significant advantage.

The numbers don’t lie: why entrepreneurs need this now

A staggering 87% of entrepreneurs experience mental health challenges, compared to only 48% of the general population. The core issue isn’t just stress — it’s the struggle to maintain top-notch performance while physically wearing down from the demands of building something worthwhile.

Additionally, studies show that gaining one more hour of sleep per week can boost your earnings by 3.4%. By not focusing on adequate rest, you are essentially losing potential income. Consider this: your competitors who emphasize recovery are not just feeling better; they’re also increasing their earnings.

The market supports this evolution. A recent report by Research and Markets indicates that the Global Biohacking Market was worth $24.5 billion in 2024 and is projected to grow to $111.3 billion by 2034. This isn’t just a fleeting trend; it’s a fundamental transformation in how peak performers pursue optimization.

What biohacking actually means for business

Biohacking isn’t some sort of mystical wellness idea. It’s driven by entrepreneurs who apply their business-oriented mindset of fine-tuning efficiency to their health. These individuals meticulously track every critical measurement.

At present, they’re monitoring their HRV (heart rate variability) as diligently as they track conversion rates, trying out intermittent fasting as if it’s a marketing strategy, and focusing on sleep optimization with the same fervor they dedicate to growth hacking. When you reflect on it, this approach is completely logical—why not measure what truly fuels your mind if you’re already measuring all other variables?

Dave Asprey figured this out when he was running a longevity nonprofit and realized he was “the only guy under 60 in the room.” All the knowledge about human optimization was stuck with older folks, while young entrepreneurs were burning themselves out. That’s when he created something entirely different.

At his 11th annual in-person Biohacking Conference (13th, including virtual events during COVID), Asprey’s approach became crystal clear. This isn’t strategic rebranding of longevity science — it’s an entirely new framework that has grown into a multibillion-dollar industry.

His definition of biohacking is laser-focused: “To change the environment outside of you and inside of you so you have full control of your biology, to allow you to upgrade your body, mind, and your life.”

AI is revolutionizing the biohacking game

Here’s where Asprey really got my attention. His company, 40 Years of Zen, utilizes AI to analyze brainwaves from top entrepreneurs and train your brain to match their patterns in five days, rather than spending 20 years meditating. For entrepreneurs who barely have time to eat lunch, this is a revolutionary concept.

But the real breakthrough is Upgrade Labs, his franchise that’s collecting 187 million data points from every client. They’re using AI to analyze your bloodwork, performance metrics, goals, and current state, then generating a personalized optimization plan. No more guessing about supplements, fasting schedules or treatments.

Asprey dropped $2.5 million figuring this out the expensive way. With AI, you don’t have to.

This is biohacking evolving from experimental to systematic. The data exists and the results are measurable. (Fair warning: accessible technology can still come with a price tag — the 40 Years of Zen retreat costs $16,000 for a five-day immersive neurofeedback experience. But compare that to the cost of burnout.)

An industry cross-pollination that signals massive growth

What blew me away at Asprey’s conference wasn’t just the technology — it was the crowd. I watched entertainment personalities like Ragga Ragnar (Queen Gilhund from Vikings) discussing their craft with medical professionals like Dr. Vince Padre, who is developing gut-healthy coffee. Tech veterans were swapping notes with food innovators, such as Oren Epstein from BioRaw, Canada’s leading vegan food distributor, about running sustainable businesses.

Even teenage entrepreneurs like George Zhou and Becket Kitaen from Buffs were there, soaking it all up. Their product is a “cheeto puff made of beef.”

When cultural influencers like Food Babe, who shares her most helpful resources here, and thought leaders like Martin Luther King III show up — connecting biohacking to mission-driven initiatives like Realize The Dream — you know something has staying power. When wellness meets social change, and both get backed by real money, that’s when markets explode.

The entrepreneurial trifecta is in full effect: users proving demand, investors bringing serious capital and cultural influencers amplifying the message. Game over.

Where the smart money is moving

The investment patterns tell the story. Money is flowing toward scalable, results-driven models — from recurring subscriptions to high-retention product ecosystems. In the U.S., we’re seeing a surge in biotech investments, fueled by consumers who are increasingly dissatisfied with one-size-fits-all solutions and demand personalized, data-driven health alternatives.

Companies like Denmark-based Puori are investing heavily in the US to set a new standard for product authenticity and transparency in the supplement space. Every batch is third-party tested for over 200 contaminants, with full results available via a QR code on the packaging, enabling consumers to make informed decisions in a crowded market. PureWave’s VEMI Biosynchronizing beds are being used to assist in veteran recovery. BioLight’s cutting-edge oral healthcare technology is redefining dental health.

As Dr. Mike Belkowski, founder of Biolight, explained at their booth: “Red Light Therapy is no longer a fringe modality— it’s becoming a cornerstone in the future of health optimization. As we unlock the science behind light, mitochondria, and cellular resilience, we’re entering a new era where healing and performance can be non-invasive, natural, and profoundly effective.”

The biggest wins? Brands are building recurring revenue around absolute trust and utility. Position yourself where performance, personalization, and prevention intersect, and you won’t just ride the biohacking wave — you’ll own it.

Building biohacking into your business culture

Asprey dropped some practical wisdom about integrating biohacking into your company culture, no matter what stage you’re in:

• Lead by Example: “You cannot tell your employees what to do unless you’re doing it.” Don’t mandate wellness programs. Show the value through your own transformation first.
• Invest in Real Health Data: “You have all the lab tests, or at least your employees do, and they get actionable information to improve them. The amount of money you will make from having employees who are emotionally regulated because they’re biologically healthy, holy crap, your whole culture changes overnight. It’s so big.”
• Go Dry: This might surprise you, but Asprey’s logic is bulletproof. “You should not be spending your hard-earned profits on feeding your employees alcohol. He says, give them high-quality coffee instead. Give them things that make them grounded and focused and happy and performant and healthier.”

These aren’t feel-good wellness initiatives. These are business strategies disguised as employee benefits.

The bottom line

Biohacking is no longer just about personal optimization. It’s about building better businesses and creating sustainable competitive advantages. While your competitors burn out on the old grind-it-out mentality, you’re optimizing your biology for sustained peak performance.

The only question is whether you’ll get ahead of this curve or spend the next five years playing catch-up while your competition evolves past you.

In my experience, winning entrepreneurs spot trends early and move fast. Biohacking isn’t the future of wellness — it’s the future of high-performance entrepreneurship.