DNA samples collected from a glove discovered near Nancy Guthrie’s home, as well as from inside her residence, have failed to yield a match in the FBI’s database, according to Pima County Sheriff Chris Nanos.

In a conversation with Fox News, Sheriff Nanos disclosed that the DNA samples obtained from the crime scene were checked against the Combined DNA Index System (CODIS) but did not correspond with any existing records. Notably, the DNA on the glove was distinct from that found inside Guthrie’s home, he confirmed.

Nancy Guthrie was reportedly abducted from her Tucson, Arizona residence during the early hours of February 1. Sheriff Nanos emphasized that she did not leave voluntarily.

“We remain hopeful that we’re closing in on answers,” Nanos shared. “Recently, we submitted the glove’s DNA for CODIS analysis, and unfortunately, we learned today that there were no matches.”

FBI agents conducted a thorough door-to-door inquiry in the vicinity of Nancy Guthrie’s Tucson home on Friday, February 6, 2026. Guthrie was last seen the previous Saturday night, and the search for her continues. (L) A portrait of Nancy Guthrie with Savannah Guthrie, courtesy of NBC, is shown. (Photo by Kat Ramirez for Fox News Digital; Courtesy of NBC)

Although the DNA from Guthrie’s home and the glove has not resulted in a database hit, the Pima County Sheriff’s Office conveyed via an X post that the analysis of DNA evidence collected at her property is ongoing.

“The DNA that was submitted to CODIS was from the set of gloves found 2 miles away. It did not trigger a match in CODIS and did not match DNA found at the property. The DNA found at the property is being analyzed & further testing needs to be done as part of the investigation,” the sheriff’s office wrote.

DNA Labs International, where the sample was sent, is closed on weekends, a spokesperson told Fox News Digital. The spokesperson added that the office was closed on Feb. 14 and 15, adding the lab is “able to be open on the weekend if it’s requested.”

Savannah Guthrie and her mother Nancy Guthrie are pictured Thursday, June 15, 2023. (Nathan Congleton/NBC via Getty Images)

Retired FBI special agent Jason Pack told Fox News Digital that investigators will likely turn to “Investigative genetic genealogy” since there wasn’t a match for the DNA in the FBI’s CODIS database.

“[Investigators] go here: Investigative genetic genealogy, or IGG, is a technique the FBI uses that combines DNA analysis from crime scenes with searching publicly available commercial genealogy databases and old-fashioned genealogy research,” Pack said. “It is completely different from CODIS, the FBI’s law enforcement DNA database that only compares crime scene DNA against people who have already been arrested or convicted.”

A growing vigil in the morning light under cloudy skies is seen at Nancy Guthrie’s home on February 13, 2026, in Tucson, Arizona. (Ty ONeil/AP Photo)

The technique was used to catch the Golden State Killer in 2018, who killed at least 13 people and sexually assaulted another 50 women after investigators uploaded DNA found at the crime scene to a genecology database and found a distant cousin. The distant cousin was used to build a family tree which eventually led investigators to Joseph DeAngelo.

Photos released on Feb. 10, 2025, show a “subject” on Nancy Guthrie’s property.  (Provided by FBI)

In an emotional video released Sunday, NBC “Today” show host Savannah Guthrie said, “it is never too late to do the right thing”.

“I just wanted to come on and say that we still have hope and we still believe. And I wanted to say to whoever has her or knows where she is. It’s never too late. And you’re not lost or alone,” Guthrie said. “We believe in the essential goodness of every human being. And it’s never too late.”

Nancy Guthrie disappearance timeline: 
Jan. 31, 2026
• Between 9:30–9:45 p.m. – Family drops Nancy off at home
• 9:50 p.m. – Garage door closes (per authorities)
Feb. 1, 2026
• 1:47 a.m. – Doorbell camera disconnects
• 2:12 a.m. – Security camera detects motion
• 2:28 a.m. – Pacemaker disconnects from phone application
• 11:56 a.m. – Family checks on Nancy after she misses weekly church livestream gathering
• 12:03 p.m. — 911 called
• 12:15 p.m. — Sheriff’s deputies arrive at home