Chelsea Handler has told Kyle Sandilands he should try Ozempic on Friday’s The Kyle and Jackie O Show.

After Kyle, 52, brought up how his weight affects the size of his manhood, the American comedian and TV star, 48, suggested the drug used by many celebrities for weight loss.

‘Why don’t you just try some Ozempic so you can have a bigger penis?’

Kyle’s co-host Jackie ‘O’ Henderson agreed: ‘I said that to him, you should try it.’

Jackie, 49, has repeatedly denied the drug is behind her own spectacular 18kg slim down. 

Ozempic, an appetite suppressant previously used to treat Diabetes type II, has seen an increase in prescriptions for obesity in recent years.

It is now used by many celebrities to keep a trim figure.

Jackie has always insisted she achieved her weight loss by going on WW (Weight Watchers), for which she was an official ambassador.

But speculation recently kicked off again after WW, under the leadership of CEO Sima Sistani, started to embrace semaglutide drugs like Ozempic.

Reacting to the news late last year on The Kyle and Jackie O Show, Jackie exclaimed, ‘That makes it look like I was definitely on Ozempic!’

She jokingly added, ‘I was like a guinea pig in that experiment.’

Newsreader Brooklyn Ross then asked Jackie if she was ‘annoyed’ she had to lose weight ‘the hard way’ instead of just using a semaglutide for a quick fix.

‘I mean, they make a good point and I’m really impressed that they’re with the times,’ she said.

‘You see so many people doing it and being successful and it not really being that hard for them.’