Nearly 50,000 people are isolated in the worst flood disaster the NSW Mid North Coast has ever seen. 

The town of Taree is the epicentre of the floods, with dozens of residents rescued from their rooftops and hundreds more fleeing their homes.

More than 100 flood warnings were in place tonight, including more than 20 emergency warnings for residents to evacuate.

Assistance will be provided in the form of grants to help low-income, uninsured individuals replace essential household items to maintain their living conditions and carry out necessary repairs on their homes.

Councils will get money to help clean up and restore public assets.

Financial support will also be extended to small businesses and producers to replace lost goods and damaged property. Additionally, primary producers will receive subsidies to cover transportation costs for replacing livestock and feed.

Due to the ongoing weather situation, Port Macquarie Airport has been closed.