Following a fungal infection outbreak tied to extensive redevelopment, two individuals have passed away at a public hospital.

Sydney’s Royal Prince Alfred Hospital (RPA) reported that six patients in its transplant unit were affected by the fungal cluster toward the end of 2025.

The infection originated from Aspergillus, a common mold typically found in soil, dust, and moist areas.

While Aspergillus generally poses little risk to healthy individuals, it can be particularly harmful to those with compromised immune systems, according to a spokesperson for the Sydney Local Health District.

“Fungal infections are a recognized hazard for patients with significantly weakened immune systems, such as those undergoing organ transplants,” the spokesperson explained.

“The district offers its heartfelt condolences to the families of the deceased patients at Royal Prince Alfred Hospital and acknowledges the profound effect on all patients and their families,” they added.

When did the outbreak happen?

The outbreak occurred between October and December 2025.

The hospital is in the middle of a $940 million redevelopment. Health authorities indicated the construction works were the cause of the fungal infections.

Infectious disease clinicians investigated the outbreak, and safety measures were ramped up, including a deep clean of the ward, upgrades to air filtration systems, and comprehensive air testing.

Patients were moved out of the transplant ward while remedial efforts were performed.

At-risk patients were given antifungal medication after consultation with clinicians.

NSW chief health officer Kerry Chant convened an expert panel to advise on risk mitigation, and it declared the ward safe to reopen on 9 February.

“RPA is a leader in transplant surgery, with nearly 60 years of experience performing kidney transplants and 40 years in liver transplants,” the district spokesman said.

“We reassure patients and the community that RPA Hospital continues to be a safe place for care, and we have put in place robust policies and procedures to help prevent any further fungal infections.”

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