Chargers vs. Jaguars, 49ers vs. Cardinals: NFL Week 11 odds, picks
Share this @internewscast.com

Matt Ehalt, the esteemed Post sports gambling editor and producer, as well as a digital sports editor, returns for another season to guide readers through the NFL Bettor’s Guide.

Chargers (-3) over JAGUARS

The narratives of the Chargers and the Jaguars seem to be on contrasting paths. The Chargers are riding a wave of success with three consecutive wins, two of which came against formidable playoff-bound teams like the Vikings and the Steelers.

On the flip side, the Jaguars have hit a rough patch, managing only one victory in their last four outings. That win came after a grueling overtime battle against the struggling Raiders. Last week’s crushing defeat to the Texans, led by Davis Mills, may very well have dampened Jacksonville’s prospects for this season.

Meanwhile, the Chargers have a golden opportunity this week to seize the top spot in the AFC West, provided they win and the Broncos stumble against the Chiefs. Los Angeles boasts a defense capable of causing significant trouble for Trevor Lawrence, especially with Jacksonville’s receiving corps in a state of disarray.

It’s possible that last week’s devastating choke against the Davis Mills-led Texans may spell doom for Jacksonville’s season, while the Chargers can move into first place in the AFC West this week with a win and a Broncos loss to the Chiefs.

Los Angeles has a defense that can give Trevor Lawrence fits, especially considering Jacksonville’s receiving room being in a state of flux.

Let’s back the better team with the better quarterback and the better coach that’s playing a better brand of football.


San Francisco 49ers tight end George Kittle (85) scores a touchdown against the Los Angeles Rams.
George Kittle and the 49ers visit the Cardinals on Sunday. IMAGN IMAGES via Reuters Connect

49ers (-2.5) over CARDINALS

The 49ers burned us last week against the Rams, but this seems like a must-win game for a team in the NFC playoff picture.

The Cardinals have played better with Jacoby Brissett as their quarterback compared to Kyler Murray, but they have lost six of seven, including last week’s 44-22 beatdown served by the Seahawks.


Betting on the NFL?


They will now have to try to find a way to win without their top two running backs and star receiver Marvin Harrison Jr., who just underwent surgery.

San Francisco’s injury-riddled defense isn’t great, as shown last week when it allowed 42 points, but Robert Saleh can attempt to neutralize star tight end Trey McBridge on each play.

We’re going to back the team that has much more at stake versus the franchise already dealing with headlines about whether its pricey quarterback will still be on the roster in 2026.

2025 record: 5-14-1
Last week: 0-2; 49ers (L); Panthers (L)

Why Trust New York Post Betting

Matt Ehalt has been picking against the spread since his childhood days when he entered his father’s newspaper pool and even took the top prize on more than one occasion. He specializes in NFL wagers and is quite successful with NCAA brackets.

Share this @internewscast.com
You May Also Like
Berlin Blackout: Leftist Sabotage Sparks Prolonged Power Crisis Amid Brutal Cold Snap

Berlin Power Crisis: Leftist Sabotage Allegations Surface as City Battles Severe Winter Blackout

While recent instances of leftist violence in the United States have grabbed…
Eerie surveillance video shows 'person of interest' in unsolved Ohio dentist murder case

Surveillance Footage Reveals ‘Person of Interest’ in Unsolved Ohio Dentist Murder Investigation

Surveillance footage has surfaced, offering a chilling glimpse into the mystery surrounding…
Rep. Doug LaMalfa of California dies, reducing GOP’s narrow control of the House to 218-213

California Representative Doug LaMalfa Passes Away, Narrowing GOP’s House Majority to 218-213

WASHINGTON (AP) — California Republican Doug LaMalfa, a longstanding U.S. Representative with…
Suspect in Vance home vandalism has had multiple run-ins with the law, demanded to be called Julia

Repeat Offender in Vance Home Vandalism Case Insists on Being Addressed as Julia

The man apprehended in connection with the vandalism incident at Vice President…
Who’s who in Maduro case: The judge, prosecutors and defense lawyers now facing off

Key Players in the Maduro Case: The Judge, Prosecutors, and Defense Attorneys Engaged in Legal Battle

Nicolas Maduro, the former leader of Venezuela known for his far-left policies,…
One detained and another injured after officer-involved shooting in Arlington, police say

Arlington Police Report: One Person Detained, Another Injured in Officer-Related Shooting

The Jacksonville Sheriff’s Office reported a tense situation on Monday night, where…
Jacksonville police release bodycam video of officer-involved shooting during December standoff

Jacksonville Police Unveil Shocking Bodycam Footage of December Standoff Shooting

Newly released 911 recordings and footage from body cameras unveil the events…
Iran protests prompt new Trump warning over deadly government crackdowns

Trump Issues Stark Warning as Iran’s Government Faces Global Backlash Over Deadly Protest Crackdowns

On Sunday evening, President Donald Trump issued a stern warning to the…
Illinois influenza death: Flu-like illness activity at highest rate, linked to new Subclade K variant, IDPH, CDC say

Illinois Faces Surge in Influenza Deaths as New Subclade K Variant Intensifies Flu-like Illness Activity, Warns IDPH and CDC

In a somber announcement, Illinois authorities have reported the first pediatric death…
Hegseth censures Senator Mike Kelly after video urging troops to resist unlawful orders, could lead to military retirement cut

Hegseth Criticizes Senator Mike Kelly Following Controversial Video Urging Troops to Defy Unlawful Orders, Potentially Affecting Military Retirement Benefits

WASHINGTON — In a significant move, Defense Secretary Pete Hegseth announced on…
Trial underway for former Uvalde school police officer accused of slow response to shooting

Ex-Uvalde Officer Faces Trial: Examining Accountability in School Shooting Response

Opening statements are scheduled for Tuesday in the trial of a former…
Asking Eric: Siblings stage hearing aid ‘intervention’

Siblings Conduct Intervention to Address Eric’s Hearing Aid Needs

Dear Eric: I’m 60 and have been dealing with hearing loss since…