Chargers vs. Jaguars, 49ers vs. Cardinals: NFL Week 11 odds, picks
Share this @internewscast.com

Matt Ehalt, the esteemed Post sports gambling editor and producer, as well as a digital sports editor, returns for another season to guide readers through the NFL Bettor’s Guide.

Chargers (-3) over JAGUARS

The narratives of the Chargers and the Jaguars seem to be on contrasting paths. The Chargers are riding a wave of success with three consecutive wins, two of which came against formidable playoff-bound teams like the Vikings and the Steelers.

On the flip side, the Jaguars have hit a rough patch, managing only one victory in their last four outings. That win came after a grueling overtime battle against the struggling Raiders. Last week’s crushing defeat to the Texans, led by Davis Mills, may very well have dampened Jacksonville’s prospects for this season.

Meanwhile, the Chargers have a golden opportunity this week to seize the top spot in the AFC West, provided they win and the Broncos stumble against the Chiefs. Los Angeles boasts a defense capable of causing significant trouble for Trevor Lawrence, especially with Jacksonville’s receiving corps in a state of disarray.

It’s possible that last week’s devastating choke against the Davis Mills-led Texans may spell doom for Jacksonville’s season, while the Chargers can move into first place in the AFC West this week with a win and a Broncos loss to the Chiefs.

Los Angeles has a defense that can give Trevor Lawrence fits, especially considering Jacksonville’s receiving room being in a state of flux.

Let’s back the better team with the better quarterback and the better coach that’s playing a better brand of football.


San Francisco 49ers tight end George Kittle (85) scores a touchdown against the Los Angeles Rams.
George Kittle and the 49ers visit the Cardinals on Sunday. IMAGN IMAGES via Reuters Connect

49ers (-2.5) over CARDINALS

The 49ers burned us last week against the Rams, but this seems like a must-win game for a team in the NFC playoff picture.

The Cardinals have played better with Jacoby Brissett as their quarterback compared to Kyler Murray, but they have lost six of seven, including last week’s 44-22 beatdown served by the Seahawks.


Betting on the NFL?


They will now have to try to find a way to win without their top two running backs and star receiver Marvin Harrison Jr., who just underwent surgery.

San Francisco’s injury-riddled defense isn’t great, as shown last week when it allowed 42 points, but Robert Saleh can attempt to neutralize star tight end Trey McBridge on each play.

We’re going to back the team that has much more at stake versus the franchise already dealing with headlines about whether its pricey quarterback will still be on the roster in 2026.

2025 record: 5-14-1
Last week: 0-2; 49ers (L); Panthers (L)

Why Trust New York Post Betting

Matt Ehalt has been picking against the spread since his childhood days when he entered his father’s newspaper pool and even took the top prize on more than one occasion. He specializes in NFL wagers and is quite successful with NCAA brackets.

Share this @internewscast.com
You May Also Like
'Paradise' star and author Sarah Shahi reveals what helped her build her dream life and some 'Paradise' secrets

Unlocking ‘Paradise’: Sarah Shahi Shares Her Secrets to Crafting a Dream Life and Behind-the-Scenes Insights

Renowned actress Sarah Shahi is now venturing into the literary world with…
Exiled Iranian crown prince reveals 6-step plan to exert pressure on Tehran's regime

Iran’s Exiled Crown Prince Unveils Strategic 6-Step Plan to Challenge Tehran’s Regime

Reza Pahlavi, the exiled crown prince of Iran, revealed a strategic 6-step…
Ohio dentist murders gun match a ‘big problem’ for surgeon ex: Defense attorney

Ohio Dentist Murder Case: Forensic Gun Evidence Poses Major Challenge for Surgeon Ex-Partner

A gun retrieved from Michael McKee’s property in Illinois has been preliminarily…
Jacksonville woman arrested after allegedly punching trooper during ICE confrontation, Florida AG says

Florida AG Reports Jacksonville Woman’s Arrest Following Alleged Assault on Trooper During ICE Encounter

A woman named Jennifer Cruz was apprehended on Tuesday, facing multiple charges…
A prosecutor’s child witnessed Charlie Kirk’s assassination — can he take part in the case?

Prosecutor’s Involvement Questioned After Child Witnesses Charlie Kirk’s Assassination

PROVO, Utah — The defense team for a Utah electrician, charged with…
Key accuser in Alexander brothers rape case dies just one week before federal trial begins: report

Tragic Twist: Key Witness in Alexander Brothers Rape Trial Passes Away Days Before Federal Proceedings Commence

The woman whose initial accusations against Oren and Alon Alexander led to…
Secret Service aware after Iranian state TV airs Trump threat featuring photo of Butler assassination attempt

Iranian State TV Airs Chilling Trump Threat: Secret Service Alerted After Broadcast Features Butler Assassination Image

Earlier this week, Iranian state television broadcast a disturbing threat aimed at…
Readers sound off on housing for seniors, defunding ICE and a gifted Nobel prize

Public Weighs In on Senior Housing, ICE Budget Cuts, and Recent Nobel Prize Award

Help seniors stay in their homes and get care In Manhattan, Governor…
Illegal alien with 24 convictions among ‘worst of the worst’ arrested in Minnesota ICE operation: DHS

Minnesota ICE Operation Captures Notorious Offender with 24 Convictions, Says DHS

In a significant development, the Department of Homeland Security (DHS) announced on…
UNRWA officials lobby congressional staffers against Trump terrorist designation threat

UNRWA Officials Urge U.S. Congress to Reject Trump’s Proposed Terrorist Labeling

EXCLUSIVE: In a recent briefing, officials from the United Nations Relief and…
Fox News True Crime Newsletter: Virginia nanny's story, dentist murders charges, Barry Morphew's plea

Unveiling the Virginia Nanny’s Tale, Dentist Murder Indictments, and Barry Morphew’s Latest Court Move in True Crime News

In the Fairfax County Circuit Court on January 14, 2026, Brendan Banfield…
ICE releases photos after violent Minneapolis protests leave multiple alleged agitators arrested

ICE Releases Images Following Arrests of Alleged Agitators During Minneapolis Protests

On Friday, U.S. Immigration and Customs Enforcement (ICE) unveiled images of four…