Chargers vs. Jaguars, 49ers vs. Cardinals: NFL Week 11 odds, picks
Share this @internewscast.com

Matt Ehalt, the esteemed Post sports gambling editor and producer, as well as a digital sports editor, returns for another season to guide readers through the NFL Bettor’s Guide.

Chargers (-3) over JAGUARS

The narratives of the Chargers and the Jaguars seem to be on contrasting paths. The Chargers are riding a wave of success with three consecutive wins, two of which came against formidable playoff-bound teams like the Vikings and the Steelers.

On the flip side, the Jaguars have hit a rough patch, managing only one victory in their last four outings. That win came after a grueling overtime battle against the struggling Raiders. Last week’s crushing defeat to the Texans, led by Davis Mills, may very well have dampened Jacksonville’s prospects for this season.

Meanwhile, the Chargers have a golden opportunity this week to seize the top spot in the AFC West, provided they win and the Broncos stumble against the Chiefs. Los Angeles boasts a defense capable of causing significant trouble for Trevor Lawrence, especially with Jacksonville’s receiving corps in a state of disarray.

It’s possible that last week’s devastating choke against the Davis Mills-led Texans may spell doom for Jacksonville’s season, while the Chargers can move into first place in the AFC West this week with a win and a Broncos loss to the Chiefs.

Los Angeles has a defense that can give Trevor Lawrence fits, especially considering Jacksonville’s receiving room being in a state of flux.

Let’s back the better team with the better quarterback and the better coach that’s playing a better brand of football.


San Francisco 49ers tight end George Kittle (85) scores a touchdown against the Los Angeles Rams.
George Kittle and the 49ers visit the Cardinals on Sunday. IMAGN IMAGES via Reuters Connect

49ers (-2.5) over CARDINALS

The 49ers burned us last week against the Rams, but this seems like a must-win game for a team in the NFC playoff picture.

The Cardinals have played better with Jacoby Brissett as their quarterback compared to Kyler Murray, but they have lost six of seven, including last week’s 44-22 beatdown served by the Seahawks.


Betting on the NFL?


They will now have to try to find a way to win without their top two running backs and star receiver Marvin Harrison Jr., who just underwent surgery.

San Francisco’s injury-riddled defense isn’t great, as shown last week when it allowed 42 points, but Robert Saleh can attempt to neutralize star tight end Trey McBridge on each play.

We’re going to back the team that has much more at stake versus the franchise already dealing with headlines about whether its pricey quarterback will still be on the roster in 2026.

2025 record: 5-14-1
Last week: 0-2; 49ers (L); Panthers (L)

Why Trust New York Post Betting

Matt Ehalt has been picking against the spread since his childhood days when he entered his father’s newspaper pool and even took the top prize on more than one occasion. He specializes in NFL wagers and is quite successful with NCAA brackets.

Share this @internewscast.com
You May Also Like
Details emerge on CIA unit alleged National Guard shooter served with in Afghanistan

New Revelations: Former National Guardsman’s Ties to CIA Unit in Afghanistan Uncovered

In a chilling incident just before Thanksgiving, an Afghan national named Rahmanullah…
Colorado tourist found dead in Tobago with 'metal object protruding from back'

Tragic Incident: Colorado Tourist Discovered Dead in Tobago with Mysterious Metal Object

A Colorado-based tourist met a tragic fate in Tobago, where he was…
Linda Hamilton, 69, on aging in Hollywood and why she's 'earned' her face

Linda Hamilton, 69, Embraces Aging and Celebrates Her Natural Beauty in Hollywood Spotlight

Linda Hamilton embraces who she is with confidence. The 69-year-old actress, renowned…
Angel Families thank Trump in new Thanksgiving video for his border security efforts: 'We appreciate you'

Angel Families Praise Trump’s Border Security Achievements in Heartfelt Thanksgiving Tribute

The American Border Story (TABS) has launched a compelling new video, showcasing…
Tyler Thompson ID'd as woman arrested after video shows dog being thrown over fence in plastic bag in Anaheim, California

Woman Identified as Tyler Thompson Arrested for Allegedly Throwing Dog Over Fence in Anaheim Video Incident

Anaheim, Calif. — A disturbing incident has led to the arrest of…
Nigerian children as young as 5 among hundreds kidnapped, nun says

Tragic Rise in Kidnappings: Nigerian Children, Some Just 5, Among Victims

A significant number of children abducted from a Catholic school in Nigeria…
Rev. Jesse Jackson health: Civil rights activist recovering as Rainbow PUSH Coalition hosts annual Thanksgiving event, family says

Rev. Jesse Jackson on the Mend: Civil Rights Icon Recuperates as Rainbow PUSH Coalition Celebrates Annual Thanksgiving Event

Thursday marked a significant milestone as the Rainbow PUSH Coalition hosted its…
Trump administration to reexamine green cards issued to people from 'every country of concern'

Trump Administration’s Green Card Review Targets High-Risk Countries: What You Need to Know

According to U.S. Citizenship and Immigration Services Director Joseph B. Edlow, a…
Jacksonville prepares Black Friday traffic plan after 2024 gridlock at St. Johns Town Center

Jacksonville Develops Strategic Traffic Plan for Black Friday Following 2024 St. Johns Town Center Congestion

The Jacksonville police are gearing up for the influx of shoppers at…
Chicago-area doctors worry over subclade K flu strain ahead of Thanksgiving 2025 holiday

Chicago Doctors Sound Alarm on Emerging K Flu Strain Threatening Thanksgiving 2025 Travel Plans

ELMHURST, Ill. — As the holiday season approaches, a surge of concern…
US passenger goes missing while on shore during Caribbean cruise

U.S. Passenger Disappears During Caribbean Cruise Shore Excursion: Urgent Search Underway

A 55-year-old American woman disappeared during a Caribbean cruise tour after stepping…
Temple staff stunned to hear knocking from inside coffin brought in for cremation

Temple Staff Shocked by Unexpected Sounds from Coffin During Cremation Ceremony

A 65-year-old woman from Thailand, presumed dead, shocked temple workers in Bangkok…