DEA warning of heightened threat as synthetic drugs creep at alarming rates into Chicago's illicit drug market

In Chicago, there’s a rising alarm among authorities about dangerous drug mixtures flooding the city’s illicit market. A new alert has been issued by the area’s chief drug enforcement agency, urging parents and children to be cautious as these lethal combinations become more prevalent.

The Drug Enforcement Administration’s Chicago Field Division is particularly concerned about the increasing prevalence of fentanyl—a highly potent opioid—being combined with synthetic tranquilizers at unprecedented levels. This alarming trend is raising red flags across the city.

ABC7 Chicago is now streaming 24/7. Click here to watch

In a conversation with the ABC7 I-Team, Todd Smith, the Special Agent in Charge of the DEA Chicago, emphasized the grave risk posed by these toxic cocktails. He noted the marked increase in their presence within the Chicago area, underscoring the urgent need for awareness and caution.

Smith highlighted a critical issue: traditional overdose treatments like Narcan are ineffective against these combinations. “The biggest challenge with xylazine and medetomidine is that Narcan will not reduce. Narcan will not reverse if you go into an overdose,” he explained.

Xylazine and medetomidine, both synthetic tranquilizers typically used for animals, are not opioids. When these substances are mixed with fentanyl in pill or powder form, they render Narcan ineffective in reversing overdoses.

In some instances, surviving an overdose from these mixtures may require more drastic, physical intervention, further complicating the efforts of first responders and healthcare professionals.

“You have to administer CPR to keep that person alive. If you don’t, they’re going to die,” explained Smith, who also said because of renewed relations with the Mexican government to intercept fentanyl precursors into the country, cartels have been forced to pivot to keep their product potent with hazardous new blends.

RELATED | DEA Chicago’s new top enforcer discusses priorities, battling cartel influence in drug trafficking

“We’ve been working for years with the government of Mexico, but most recently, there has been better collaboration with the Mexican government to go after these foreign terrorist organizations. To try to intercept those shipments before they arrive to Mexico and can be put into the illicit drug supply market,” Smith said.

And while the DEA is fervently fighting fentanyl and other deadly drugs, it’s not lost on the city’s top drug enforcer there are other substances of concern where the DEA does not have jurisdiction such as tianeptine , also known as gas station heroin. Over the counter sales in Illinois are now prohibited but recently the drug was blamed for a death in Pennsylvania.

“The real challenge is, is getting people prosecuted when the laws don’t exist, we can’t prosecute people,” Smith said. “So, we’ve got a lot of threats facing us in the Chicago area. You know, we’re laser focused on illicit fentanyl and what’s driving overdoses, but we’re keenly aware of these, these highly addictive substances being sold at smoke shops and gas stations.”

Smith also emphasized the warning comes at an inflection point in the year as many young people are gathering for summer activities and celebrating transitions to high school and college. He is asking parents to have the conversation: if you don’t know where it’s from, don’t put it in your body.

Copyright © 2026 WLS-TV. All Rights Reserved.

Leave a Reply

Your email address will not be published. Required fields are marked *

You May Also Like
ISS faces another air leak after problem first appeared in 2019

ISS Confronts Persistent Air Leak Challenge: Concerns Resurface After Initial 2019 Incident

The International Space Station is once again experiencing air leaks. NASA confirmed…
Two-time loser Curtis Sliwa eying another NYC mayoral run in 2029

Can Curtis Sliwa Break the ‘Two-Time Loser’ Streak in 2029 NYC Mayoral Race?

For the third time, Curtis Sliwa, a former Republican contender for New…
Marcia Lucas, Oscar-winning 'Star Wars' editor and former wife of George Lucas, dies at 80

Oscar-Winning ‘Star Wars’ Editor and Former Spouse of George Lucas, Marcia Lucas, Passes Away at 80

For women seeking significant creative roles in Hollywood, the position of editor…
Virginia bus crash: Driver Jing S. Dong charged in I95 crash; Dmitri and Ecaterina Doncev, Priscilla Mafalda among the victims

Virginia Bus Collision: Driver Jing S. Dong Faces Charges in I95 Incident; Victims Include Dmitri and Ecaterina Doncev, Priscilla Mafalda

A heart-wrenching tragedy unfolded on a Virginia highway when a Massachusetts family…
Spencer Pratt gets most support in these LA neighborhoods, new poll shows

Spencer Pratt’s Popularity Surges: New Poll Reveals Top Supportive Neighborhoods in Los Angeles

Spencer Pratt is amassing considerable backing in strategic areas across Los Angeles,…
32nd annual ABC7 Chicago Gibbons Run fundraiser in support of Leukemia Research Foundation at Montrose Harbor

Join the Fight Against Leukemia: ABC7 Chicago’s 32nd Annual Gibbons Run Takes Over Montrose Harbor

CHICAGO — A vibrant crowd of participants gathered for the 32nd annual…
Republican candidate Steve Hilton demands Chad Bianco drop out of CA governor race

Republican Showdown: Steve Hilton Urges Chad Bianco to Exit California Governor Race

Steve Hilton, a Republican candidate for governor, has issued a pressing request…
Search underway for 4 Alabama inmates who escaped correctional center

Intense Manhunt Launched for Four Escaped Alabama Inmates

Authorities in central Alabama are actively searching for four inmates who made…
Californians disapprove of Governor Gavin Newsom in latest poll

New Poll Reveals Growing Discontent with Governor Gavin Newsom Among Californians

Governor Gavin Newsom’s performance has sparked a division among primary voters, as…
Capitol rioters clamor for payouts from Trump's new 'anti-weaponization' fund despite backlash

Capitol Rioters Seek Compensation from Trump’s ‘Anti-Weaponization’ Fund Amid Controversy

David Johnston, a former lawyer, took part in the Capitol riot with…
Feel-Good Friday: Young Man Becomes HS Grad, Finishes 'Boot Camp'—Walks in His Marine Corps Uniform

Heartwarming Milestone: Young Man Graduates High School and Completes Boot Camp, Honored in Marine Corps Uniform

One of the remarkable aspects of Alabama is its profound respect and…
Feds push back on sanctuary policies to keep dangerous illegal immigrants in custody

Federal Authorities Challenge Sanctuary Policies to Retain Custody of High-Risk Undocumented Immigrants

California’s sanctuary-state policies are drawing sharp criticism for allegedly compromising public safety.…