The Iranian regime’s continued possession of critical sites and materials for nuclear weapons development, particularly highly enriched uranium, has prompted renewed efforts from the U.S. and Israel to dismantle the last remnants of Iran’s nuclear program.

In a recent assertion, the Israel Defense Forces (IDF) announced that its Air Force had targeted the Arak Heavy Water Plant, a central element in Iran’s plutonium production for nuclear arms. This facility is situated in the heart of Iran.

Anticipating the strike, an IDF spokesperson indicated to Fox News Digital that there is a strong likelihood that uranium enrichment sites are being included in their plans for future operations.

While the IDF has refrained from disclosing further specifics about their target list, it remains unclear if any initiatives to capture nuclear weapons-grade uranium through ground operations are underway.

An infographic released by the IDF highlights the strategic importance of the Arak heavy water plant, labeling it as a crucial infrastructure for producing plutonium.

Meanwhile, Reuters, drawing on information from the Iranian regime’s Fars news agency, reported that coordinated U.S.-Israeli attacks on Friday targeted the Khondab heavy water research reactor, another significant site in the nuclear landscape of Iran.

A statement released by the IDF said, “Heavy water is a unique material used to operate nuclear reactors, such as the inactive Arak reactor, which was originally designed to have weapons-grade plutonium production capabilities. These materials can also be used as a neutron source for nuclear weapons.

“The plant was a significant economic asset for the terror regime and served as a source of income for the Iranian Atomic Energy Organization, generating tens of millions of dollars for the regime each year.”

The regime’s foreign minister posted a condemnation of Israel and warned the Jewish state, “Iran will exact HEAVY price for Israeli crimes.”

According to an article published by the Washington, D.C.-based Institute for Science and International Security (ISIS), “The IR-40 Arak, aka Khondab, Heavy Water Reactor and Heavy Water Production Plant date to the early 2000s. … The reactor core design was ideal for making substantial amounts of weapon-grade plutonium for nuclear weapons.”

Jason Brodsky, the policy director of United Against Nuclear Iran (UANI), told Fox News Digital, “The one nuclear site which hasn’t been hit to date has been Pickaxe Mountain, so striking that site as part of Operation Epic Fury will be important to further degrade the Iranian nuclear program.”

A White House spokesperson referred Fox News Digital to President Trump’s Cabinet meeting comments about Iran’s nuclear weapons program. 

“We’re free to roam over their cities and towns and destroy all of their crazy nuclear weapons and missiles and drones that they’re building,” Trump said Thursday.

A map shows damage to Iran’s Fordow nuclear site after being struck by the United States during Operation Midnight Hammer June 22, 2025. (Fox News)

David Albright, a physicist, founder and president of the Institute for Science and International Security, told Fox News Digital that with respect to key nuclear weapons facilities that remain, “The elephants in the tent are Natanz and Isfahan. There was an attack on Natanz that the Iranians revealed, but the Israelis said we are not aware of an attack. So, it must have been the U.S.”

He said Natanz has enriched uranium. 

“The Iranians were doing recovery operations in the underground fuel enrichment plant there and continuing to build this Pickaxe Mountain tunnel complex, which could hold enriched uranium. Right next to it is another tunnel complex that was built much earlier, around 2007. … And the Iranians sealed it up, fortified it. There is something obviously important there.”

Albright said U.S. and Israeli airstrikes “have not attacked the underground Isfahan site. We know, according to the IAEA [International Atomic Energy Agency], highly enriched uranium is in that site. There may be an enrichment plant under construction in that underground complex. We would like that site to be attacked.”

Iranian worshipers hold up their hands as signs of unity with Iran’s Supreme Leader, Ayatollah Ali Khamenei, during an anti-Israeli rally to condemn Israel’s attacks on Iran in downtown Tehran, Iran, June 20, 2025.  (Morteza Nikoubazl/NurPhoto via Getty Images)

Albright warned that the war should not end like the previous U.S.-Israel war with Iran in 2025 with Tehran retaining the “crown jewels” of its atomic weapons program — highly enriched uranium and a number of centrifuges.

“You don’t want it to come out of this war with the same kind of nuclear weapons capabilities that it had at the end of June war with a higher incentive to build a bomb,” Albright said. That is why it’s so important “to finish the job” in Iran, he added.