In a significant victory against organized crime, Mexico’s Defense Department announced on Sunday that Nemesio Oseguera, the notorious drug lord known as “El Mencho,” was killed during a military operation. This development comes amid heightened pressure from former U.S. President Donald Trump for Mexico to intensify its crackdown on drug cartels.

The announcement coincides with warnings from government officials about potential clashes in the state of Jalisco and an upsurge in criminal activities nationwide. In response, the U.S. Embassy in Mexico has advised residents in several states to stay indoors.

Mexican military forces reportedly conducted operations in Tapalpa, Jalisco, aiming to capture Nemesio Rubén Oseguera Cervantes. A former police officer, Oseguera Cervantes transformed into the elusive leader of the Cartel de Jalisco Nueva Generación (CJNG), a principal source of fentanyl for the United States.

Referred to as “El Mencho,” Oseguera Cervantes had a $15 million bounty placed on him by the U.S. government. Following the detention of Joaquín “El Chapo” Guzmán, the former Sinaloa Cartel leader, El Mencho rose to prominence. Under his leadership, the CJNG expanded from a regional group to a global drug trafficking powerhouse, with Jalisco as its central hub.

El Mencho met his end during a Mexican military operation in Jalisco on February 22, 2026.

U.S. Deputy Secretary of State Christopher Landau shared his thoughts on the operation via a post on social media platform X, stating, “I’ve just been informed that Mexican security forces have killed ‘El Mencho,’ one of the bloodiest and most ruthless drug kingpins. This is a great development for Mexico, the US, Latin America, and the world. The good guys are stronger than the bad guys.”

The Mexican Defense Department said the operation was conducted as part of bilateral coordination and cooperation with the U.S., whose authorities provided complementary intelligence that contributed to Oseguera Cervantes’ capture.

During the capture, the CJNG ringleader became wounded and died en route to Mexico City, the Defense Department said.

Smoke rises into the sky over Puerto Vallarta during an operation targeting cartel activity on Feb. 22, 2026. (Obtained by Fox News Digital)

Four others were reportedly killed in at the scene of a shootout between Mexican troops and criminal suspects in Jalisco, with Oseguera Cervantes among three additional individuals who were wounded and later died.

Authorities said they detained two other members of the criminal organization and seized a range of weaponry, including armored vehicles and “rocket launchers capable of downing aircraft and destroying armored vehicles.”

Consequently, three members of the armed forces became injured and are receiving treatment. 

Four others were reportedly killed in a Jalisco shootout during the operation (Gabriel Trujillo/Reuters)

Widespread criminal activity has been reported in Jalisco, the cartel’s stronghold, as well as in northern regions that serve as key border and transit corridors for the organization.

The Security Cabinet of the Government of Mexico noted that multiple buildings were reportedly damaged during the “violent incidents,” including roughly 20 branches of Banco del Bienestar, a state-run banking institution. 

At least 21 highways remain blocked, with authorities reporting that five have already been reopened.

Photos showed numerous roadblocks and burning vehicles, with dark smoke rising into the sky, across the country – tactics officials say cartels often use to slow or block military operations. 

Photos and videos shared with Fox News Digital show thick, dark smoke rising over the skyline of the tourist city of Puerto Vallarta on Mexico’s Pacific Coast in Jalisco.

Widespread criminal activity has been reported in Jalisco, the cartel’s stronghold. (Obtained by Fox News Digital)

“I’m watching the scenes of violence from Mexico with great sadness and concern. It’s not surprising that the bad guys are responding with terror. But we must never lose our nerve,” Landau said.

The Mexican National Guard and Army units from central Mexico and states neighboring Jalisco are currently mobilizing to reinforce security, the Defense Department said.

 “We remain in Code Red. We reiterate the recommendation to avoid leaving your homes. The clashes are occurring in several federal entities,” Jalisco state Governor Pablo Lemus Navarro added. 

At least 21 highways remain barricaded. (Michelle Freyria/Reuters)

Travel warnings have been issued for Jalisco, including Puerto Vallarta, Chapala, and Guadalajara; Tamaulipas, including Reynosa and other municipalities; and parts of Michoacán, Guerrero, and Nuevo León.

“Due to ongoing security operations and related road blockages and criminal activity, U.S. citizens in the named locations should shelter in place until further notice,” the U.S. Embassy & Consulates in Mexico said. 

Complementary intelligence from U.S. authorities aided in the operation. (Michelle Freyria/Reuters)

The operation against Oseguera follows sustained pressure from the Trump administration on President Claudia Sheinbaum’s government, urging Mexico to step up its fight against drug trafficking amid threats of potential U.S. intervention.