'Benadryl challenge' leads to one death and hospitalizes more

In a troubling resurgence, the perilous “Benadryl challenge” has once again surfaced on TikTok, prompting urgent warnings from health professionals to both parents and teenagers. This dangerous trend, which first emerged six years ago, involves the intentional consumption of excessive amounts of Benadryl to experience a high while battling its sedative effects.

Benadryl, a well-known antihistamine, contains diphenhydramine as its active ingredient. This medication is typically used to alleviate symptoms associated with allergies or the common cold, such as sneezing or a runny nose. However, when misused, the consequences can be dire.

Overdosing on Benadryl can lead to severe medical complications, including increased heart rate, urinary retention that may result in kidney issues, and arrhythmia, which is characterized by an irregular heartbeat. Such side effects highlight the significant risks associated with this alarming social media challenge.

In one alarming incident, a 14-year-old girl experienced a seizure after engaging in the challenge, underscoring the potential for serious harm. Dr. Stephanie Felton, who serves as the associate medical director for the Cook Children’s emergency department in Texas, shared with the Fort Worth Star-Telegram that the hospital has already reported one tragic death linked to this hazardous trend.

One case saw a 14-year-old female who had a seizure after participating in the Benadryl challenge.

Dr. Stephanie Felton, associate medical director for the Cook Children’s emergency department in Texas, told the Fort Worth Star-Telegram that the hospital saw one recent death in connection to the deadly challenge.

The emergency department has also treated more than 100 patients in the last six months for Benadryl overdose, according to the health system.

However, Felton said that they aren’t seeing as many overdoses as they did in 2020, when the trend first emerged — but the resurgence, which is primarily affecting teens and pre-teens, is concerning.

In 2020, the trend was such an issue that the FDA issued a warning about the dangers of taking high doses of the allergy medicine, which is widely available over-the-counter without a prescription.

The Food and Drug Administration warned that taking high doses of Benadryl can lead to heart problems, seizures, coma or even death.


Bottle of Benadryl allergy medicine with scattered pink pills on a blue background.
The challenge provokes people to purposely take too much Benadryl and fight the drowsy side effects that come with it, which will produce a high. Rusty – stock.adobe.com

“We are aware of news reports of teenagers ending up in emergency rooms or dying after participating in the ‘Benadryl Challenge’ encouraged in videos posted on the social media application TikTok,” the agency said in a notice at the time.

“We are investigating these reports and conducting a review to determine if additional cases have been reported. We will update the public once we have completed our review or have more information to share.”

“We also contacted TikTok and strongly urged them to remove the videos from their platform and to be vigilant to remove additional videos that may be posted.”


A shopper's hand holds a box of Children's Benadryl grape-flavored chewable antihistamine tablets in a pharmacy aisle.
Cook Children’s emergency department saw one recent death in connection to the deadly challenge. Adriana – stock.adobe.com

The FDA advised parents to keep Benadryl at home out of reach and out of sight of children, and lock up any medications that could be at risk of misuse. They also warned healthcare workers to be aware of the trend.

Felton encouraged parents to have direct and honest conversations with their children about social media use and messaging they may be seeing online.

“A simple conversation and continued conversations…are important so we have an open door policy with our kids so that they know that they have a safe place to come to with these questions,” she said.

You May Also Like

Historically black LA neighborhood forces Latino run event to move

Historically Black Los Angeles Neighborhood Pushes Latino-Run Event to Relocate

A Latino running club has shifted its route out of Leimert Park,…
Missouri's top court blocks new House map favoring Republicans until voters can weigh in

Missouri Supreme Court Blocks Republican-Favored House Map Until Voters Weigh In

The Missouri Supreme Court has unanimously halted the state’s use of a…
Bystanders and police officers work together to lift a Volkswagen Beetle off an e-bike rider

Video Shows Bystanders, Police Lifting Volkswagen Off Woman Pinned in E-Bike Crash

A dramatic rescue unfolded on a busy Pennsylvania roadway after an e-bike…
Trump threatens trade with dozens of countries if Fed doesn't lower rates post-jobs report

Trump Threatens Trade If Fed Holds Rates After Jobs Data

WASHINGTON — President Trump on Friday pressed the Federal Reserve to cut…
NYPD cop accidentally shoots himself in leg inside Bronx home: report

NYPD Officer Accidentally Shoots Himself in Leg at Bronx Home

An off-duty NYPD officer reportedly shot himself in the leg Tuesday afternoon…
CHP launches 78-hour crackdown over Labor Day weekend

CHP Launches 78-Hour Labor Day Weekend Safety Crackdown

The California Highway Patrol is asking drivers across the Golden State to…
August jobs report shows U.S. added 162,000 jobs, more than double economists' forecasts

August Jobs Report: U.S. Adds 162,000 Jobs, Beating Forecasts

U.S. hiring picked up sharply in August, with employers creating 162,000 jobs…
US severs Iran’s 'financial lifelines' to NATO ally Turkey with bank sanctions: ‘Find out the hard way’

US Imposes Bank Sanctions to Cut Iran’s Financial Networks in Turkey

WASHINGTON — The Treasury Department imposed sanctions Friday on a Turkish bank…
RedState Sports Report: The Dodgers. Again.

College Football Roars Into RedState Sports Report Spotlight

From the sports desk somewhere beneath the main deck of the Good…
Terrence Bradshaw, the Wisconsin dad who tripped football player, 9, admits he was 'impulsive'

Wisconsin Dad Terrence Bradshaw Admits ‘Impulsive’ Move After Tripping 9-Year-Old Football Player

A Wisconsin father accused of tripping a 9-year-old football player as the…
Smuggler who brought migrants through tunnel under U.S.-Mexico border pleads guilty

Smuggler Pleads Guilty to Bringing Migrants Through Tunnel Beneath U.S.-Mexico Border

More than 18 months after authorities uncovered an underground tunnel beneath the…
Trump revives Iran regime change speculation with cryptic call for people to 'rise up'

Trump Fuels Iran Regime Change Speculation With Rise Up Call

President Donald Trump reignited questions about possible regime change in Iran on…