3 children die from diphenhydramine overdoses, antihistamine sold as Benadryl amid social media trend

In Stamford, Connecticut, three children have tragically lost their lives in the last two months due to overdoses of diphenhydramine, an antihistamine widely known under the brand name Benadryl. This information was confirmed by the state’s Office of the Child Advocate.

“The number of cases is alarming and definitely warrants attention,” commented Dr. Krishnan Narasimhan, who leads the family medicine department at Stamford Hospital.

While diphenhydramine has been a staple in allergy treatment, many medical professionals are now opting for more modern alternatives, moving away from this older medication.

Dr. Narasimhan highlighted the potential drawbacks of the drug, emphasizing its side effects.

“It has numerous side effects and can cross the blood-brain barrier, often leading to considerable sedation for those who take it,” he explained.

The state has withheld specific details about the victims’ ages and locations. Additionally, there has been no official connection made between these deaths and the “Benadryl Challenge,” a dangerous social media trend that initially gained notoriety in 2020 and occasionally resurfaces.

“This has been going on for years, starting with the Tide Pod Challenge, the cinnamon challenge. There’s so many things that we’ve talked to them for years and years about not doing any of these things, and they’re even considering it to talk to us first,” Stamford parent Michele Hayes said.

The challenge encourages participants to take as many as 24 tablets in 24 hours to induce hallucinations, which are then recorded and posted online.

That amount is double the recommended adult dosage and, according to doctors, can impair breathing to the point of coma and cause other toxic effects.

“You can get severely agitated. You can have extra heartbeats. Which can lead to cardiac complications and actually can lead to cardiac arrest and death,” Narasimhan said.

Doctors advise families to secure all medications.

A family friend of one victim told ABC New York affiliate WABC that a 13-year-old girl in Waterbury had Benadryl delivered through DoorDash without an ID check.

The deaths remain under investigation.

Copyright © 2026 WABC-TV. All Rights Reserved.

Leave a Reply

Your email address will not be published. Required fields are marked *

You May Also Like

Hollywood star Monet Mazur confronts three masked burglars at Hollywood Hills mansion

Monet Mazur Confronts Three Masked Burglars at Her Hollywood Hills Home

Actress Monet Mazur reportedly thwarted an attempted burglary at her Hollywood Hills…
Presidents Cup 2026 Sunday: Rally, protest planned, security heightened with Donald Trump expected at Chicago O'Hare Airport

Expected Trump Visit Brings Protest, Security to Presidents Cup

CHICAGO — President Donald Trump is expected to land at Chicago’s O’Hare…
Florida man, 76, with suspended license allegedly admits to driving under the influence of rum, cocaine

Florida Man, 76, Accused of DUI After Allegedly Admitting to Rum and Cocaine Use

A 76-year-old Florida man with a suspended driver’s license allegedly acknowledged during…
How Texas Gov. Abbott's race predicts 2026 'whipeout' for GOP: Begala

Former Clinton Adviser Paul Begala: Abbott’s Texas Race Foreshadows 2026 GOP ‘Wipeout’

Democratic strategist Paul Begala is forecasting a Republican “wipeout” in the 2026…
Kyrsten Sinema's ex-bodyguard explains why he was at her home before arrest

Kyrsten Sinema’s Former Bodyguard Explains Home Visit Before Arrest

Former Sen. Kyrsten Sinema’s former bodyguard and romantic partner says severe stress…
Hurricane Polo barrels toward Mexico as SoCal braces for dangerous surf, flooding

Hurricane Polo Nears Mexico as Southern California Braces for Dangerous Surf and Flooding

A powerful hurricane is racing toward Mexico while Southern California prepares for…
Airbnb renter turns tables on armed Florida home invader with one gunshot: cops

Airbnb Renter Shoots Armed Florida Home Invader With One Shot, Police Say

An Airbnb guest shot an 18-year-old who allegedly broke into a Fort…
Towering Topgolf nets are killing birdies: animal activists

Animal Activists Say Towering Topgolf Nets Are Killing Birds

For birds trapped in Topgolf’s massive 120-foot nets, getting caught appears to…
Accused Colombian drug kingpin extradited to California to face drug charges

Accused Colombian Drug Kingpin Extradited to California Court

A Colombian alleged narco-terrorism leader accused of commanding an armed force of…
Florida sex offender accused of babysitting-ad trap as police investigate potential interstate predator

Florida Sex Offender Accused of Using Babysitting Ad Trap; Police Probe Interstate Predator Claims

Georgia investigators are seeking possible additional victims of a convicted Florida sex…
Lee Gilley’s Texas attorney ‘never had one like this’ as accused wife killer clings to Italian lifeline

Texas Attorney Calls Lee Gilley’s Italian Lifeline Case Unprecedented

“I’ve never had a case like this.” Texas criminal defense attorney Dick…
Shocking video shows Amazon delivery driver peeing all over posh NYC apartment lobby

Video Shows Amazon Delivery Driver Urinating in Luxury NYC Apartment Lobby

A delivery gone foul. An Amazon delivery driver was caught on camera…