The Seattle Mariners and the Baltimore Orioles, both eager to regain momentum, clash in the opening game of a four-part series on Monday night. Seattle recently suffered a narrow 5-4 defeat against Detroit, while Baltimore was bested 6-4 by Toronto on Sunday. Currently, the Mariners hold a 34-32 record, with a 15-16 tally on the road this season. Meanwhile, the Orioles, standing at 31-35, have faced back-to-back losses but maintain a 19-15 home record in 2026.
The first pitch at Oriole Park at Camden Yards in Baltimore is scheduled for 6:35 p.m. ET. Historically, the Orioles have an edge in the series with a 247-213 lead, having won five of the last six encounters. In the latest odds, Seattle is favored at -129 on the money line (bet $129 to win $100), with the over/under set at 9. Before placing any bets, consider consulting the Mariners vs. Orioles predictions and betting tips from the renowned SportsLine computer model.
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The SportsLine Projection Model, which simulates every MLB game 10,000 times, is on fire, entering Week 12 of the MLB season with a remarkable 19-7 record on top-rated MLB picks. It also performed exceptionally well in 2025, particularly with home run prop bets, yielding nearly 30 units of profit. Anyone who followed its MLB betting advice at sportsbooks and on betting sites likely enjoyed significant gains.
Now, the model has turned its attention to the Mariners vs. Orioles matchup and has finalized its selections and MLB predictions. You can visit SportsLine to uncover the model’s picks. Here are some MLB odds and betting lines for the Orioles vs. Mariners game:
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Mariners vs. Orioles money line |
Mariners -131, Orioles +111 |
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Mariners vs. Orioles over/under |
9 runs |
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Mariners vs. Orioles run line |
Mariners -1.5 (+127) |
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Mariners vs. Orioles picks |
See picks at SportsLine |
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Mariners vs. Orioles streaming |
Fubo (Try for free) |
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Top Mariners vs. Orioles predictions
After 10,000 simulations of Mariners vs. Orioles, the model is over/under betting. The Over has hit in four of the past five Seattle games, and in seven of the last 10 Baltimore games. The Over is 24 of the past 47 Seattle games with two pushes against teams allowing 4.2 runs or more. The Over is also 8-2 in the last Baltimore games in which Chris Bassitt starts.
SportsLine’s model projects 1.8 total bases or more for the Mariners’ Randy Arozarena, Julio Rodriguez, Brendan Donovan and Dominic Canzone. The Orioles, meanwhile, are projected to get over 1.5 total bases or more from Gunnar Henderson and Pete Alonso. The model projects 10.1 combined runs as the Over hits 60% of the time. Get the Mariners vs. Orioles money-line pick at SportsLine.
How to make Orioles vs. Mariners picks
After simulating every pitch of Mariners vs. Orioles 10,000 times, the model also says one side of the money line has all the value. You can get that pick at SportsLine.
So who wins Orioles vs. Mariners, and which side of the money line has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.
