WASHINGTON — In a bold move early Sunday, the United States targeted three locations in Iran, stepping into Israel’s efforts to dismantle Iran’s nuclear program. This high-stakes decision aims to weaken a longtime adversary but has sparked concerns over a potential broader regional conflict, as Tehran blamed Washington for engaging in “a dangerous war.”

From the White House, U.S. President Donald Trump announced that Iran’s significant nuclear sites were “completely and fully obliterated,” during a national address.

Shortly afterward, Iran’s Foreign Minister Abbas Araghchi declared that diplomatic efforts were no longer an option and that Iran reserved the right to defend itself, accusing the U.S. of “crossing a very big red line.”

“The warmongering, a lawless administration in Washington is solely and fully responsible for the dangerous consequences and far reaching implications of its act of aggression,” he told reporters in Turkey in the first comments by a high-ranking Iranian official since the strikes.

Iran is a close ally of Russia, and has actively supported it in its war on Ukraine, supplying it with attack drones. Araghchi said he would be flying immediately to Moscow to meet with President Vladimir Putin “and coordinate our positions.”

The Atomic Energy Organization of Iran confirmed that attacks took place on its Fordo, Isfahan and Natanz sites, but it insisted that its nuclear program will not be stopped. Both Iran and the U.N. nuclear watchdog said there were no immediate signs of radioactive contamination around the three locations following the strikes.

Satellite images by Planet Labs PBC taken after the American strikes, analyzed by The Associated Press, show damage to the Fordo facility, which is dug deep into a mountain, while light gray smoke lingered in the air.

It was not clear whether the U.S. would continue attacking Iran alongside its ally Israel, which has been engaged in a war with Iran for nine days. Countries around the globe are calling for diplomacy and no further escalation. Trump acted without congressional authorization, and he also warned there would be additional strikes if Tehran retaliated against U.S. forces.

“There will either be peace or there will be tragedy for Iran,” he said.

Iran’s Foreign Ministry said Washington had “betrayed diplomacy” with the military strikes in support of Israel, and said that “the U.S. has itself launched a dangerous war against Iran.”

Hours after the U.S. strikes, Iran’s paramilitary Revolutionary Guard said it launched a barrage of 40 missiles at Israel, including its Khorramshahr-4, which can carry multiple warheads. Israeli authorities reported that more than 80 people suffered mostly minor injuries, though one multi-story building in Tel Aviv was significantly damaged, with its entire façade torn away to expose the apartments inside. Houses across the street were almost completely destroyed.

Following the Iranian barrage, Israel’s military said it had “swiftly neutralized” the Iranian missile launchers that had fired, and that it had begun a series of strikes toward military targets in western Iran.

Iran has maintained that its nuclear program is for peaceful purposes only, and U.S. intelligence agencies have assessed that Tehran is not actively pursuing a bomb. However, Trump and Israeli leaders have argued that Iran could quickly assemble a nuclear weapon, making it an imminent threat.

The decision to directly involve the U.S. in the war comes after more than a week of strikes by Israel that significantly degraded Iran’s air defenses and offensive missile capabilities, and damaged its nuclear enrichment facilities.

But U.S. and Israeli officials have said American B-2 stealth bombers and the 30,000-pound (13,500-kilogram) bunker-buster bomb that only they have been configured to carry offered the best chance of destroying heavily fortified sites connected to the Iranian nuclear program buried deep underground.

The attack on Fordo did employ bunker-buster bombs, a U.S. official said.

In addition, U.S. submarines launched about 30 Tomahawk missiles, according to another U.S. official. The two spoke on condition of anonymity to discuss military operations.

Trump appears to have made the calculation — at the prodding of Israeli officials and many Republican lawmakers — that Israel’s operation had softened the ground and presented a perhaps unparalleled opportunity to set back Iran’s nuclear program, perhaps permanently.

“We have completed our very successful attack on the three Nuclear sites in Iran, including Fordow, Natanz, and Esfahan,” Trump said in a post on social media, using common alternate spellings for two of the sites. “All planes are now outside of Iran air space. A full payload of BOMBS was dropped on the primary site, Fordow. All planes are safely on their way home.”

Trump added in a later post: “This is an HISTORIC MOMENT FOR THE UNITED STATES OF AMERICA, ISRAEL, AND THE WORLD. IRAN MUST NOW AGREE TO END THIS WAR. THANK YOU!”

The White House and Pentagon did not immediately elaborate on the operation. U.S. military leaders are scheduled to provide a briefing at 8 a.m. Eastern.

The International Atomic Energy Agency wrote on X that there has been “no increase in off-site radiation levels” after the strikes but that it would continue to monitor the situation.

The decision to attack was a risky one for Trump, who won the White House partially on the promise of keeping America out of costly foreign conflicts and scoffed at the value of American interventionism.

But Trump also vowed that he would not allow Iran to obtain a nuclear weapon, and he had initially hoped that the threat of force would bring the country’s leaders to give up its nuclear program peacefully.

For months, Trump said he was dedicated to a diplomatic push to persuade Iran to give up its nuclear ambitions. And he twice — in April and again in late May — persuaded Netanyahu to hold off on military action against Iran and give diplomacy more time.

After Israel began striking Iran, Trump went from publicly expressing hope that the moment could be a “second chance” for Iran to make a deal to delivering explicit threats on Khamenei and making calls for Tehran’s unconditional surrender.

He has bristled at criticism from some supporters who have suggested that further U.S. involvement would be a betrayal to those who were drawn to his promise to end U.S. involvement in expensive and endless wars.

Israeli Prime Minister Benjamin Netanyahu praised Trump’s decision to attack in a video message directed at the American president.

“Your bold decision to target Iran’s nuclear facilities, with the awesome and righteous might of the United States, will change history,” he said. Netanyahu said the U.S. “has done what no other country on earth could do.”

U.N. Secretary-General Antonio Guterres called the strikes a “dangerous escalation,” as world leaders began chiming in with calls for diplomacy.

“There is a growing risk that this conflict could rapidly get out of control — with catastrophic consequences for civilians, the region and the world,” he said in a statement.

Iranian-backed Houthi rebels in Yemen, who had threatened to resume attacks on U.S. vessels in the Red Sea if the Trump administration joined Israel’s military campaign, called on other Muslim nations to form “one front against the Zionist-American arrogance.”

Iran’s Supreme Leader Ayatollah Ali Khamenei had warned the United States on Wednesday that strikes targeting the Islamic Republic will “result in irreparable damage for them.” And Iranian Foreign Ministry spokesman Esmail Baghaei declared “any American intervention would be a recipe for an all-out war in the region.”

The Israeli military said Saturday it was preparing for the possibility of a lengthy war, while Iran’s foreign minister warned before the U.S. attack that American military involvement “would be very, very dangerous for everyone.”

Israeli strikes on Iran have killed at least 865 people and wounded 3,396 others, according to the Washington-based group Human Rights Activists. The group said of those dead, it identified 363 civilians and 215 security force personnel.

Trump’s decision for direct U.S. military intervention comes after his administration made an unsuccessful two-month push — including with high-level, direct negotiations with the Iranians — aimed at persuading Tehran to curb its nuclear program.

During his previous administration, Trump pulled the U.S. unilaterally out of the 2015 nuclear deal with Iran, prompting Tehran to begin enriching uranium to higher levels and restrict the access of IAEA inspectors to its facilities.

Madhani reported from Morristown, N.J. Associated Press writers Nasser Karimi, Mehdi Fattahi and Amir Vahdat in Iran; Julia Frankel in Jerusalem; Melanie Lidman in Tel Aviv; Lolita Baldor in Narragansett, Rhode Island; Samy Magdy in Cairo; and Farnoush Amiri in Dubai contributed to this story.

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