The major public health authority in the U.S. is currently dealing with significant disruptions and is without leadership, as efforts are underway from the White House to remove its chosen director from the Centers for Disease Control and Prevention. On Thursday, three high-ranking officials were also seen being escorted out of its headquarters.

Such upheaval has sparked uncommon concern shared across political lines. The health secretary under President Donald Trump, Robert F. Kennedy Jr., is attempting to promote anti-vaccine measures, which have been refuted by years of scientific evidence.

This disorder arises just weeks ahead of an important advisory group meeting, which Kennedy has restructured with individuals skeptical of vaccines, to provide new immunization guidelines.

Amidst the chaos, two Republican senators have demanded a congressional investigation, while some Democrats contend that Kennedy should be dismissed. He is set to present his testimony on Capitol Hill on September 4.

Kennedy has not clarified why he dismissed Susan Monarez from her role as CDC director shortly after her appointment, though he hinted at potential further dismissals.

“There’s significant unrest within the CDC, and removing some personnel over time is essential for reforming the organizational culture,” Kennedy commented during a press briefing in Texas.

The White House has only said that Monarez was “not aligned with” Trump’s agenda. There is no word on when a replacement could be named.

Monarez’s lawyers said that she refused “to rubber-stamp unscientific, reckless directives and fire dedicated health experts.” She is fighting her dismissal, saying the decision must come directly from Trump, who nominated her in March.

The saga began Wednesday night with the administration’s announcement that Monarez would no longer lead the CDC. In response, three officials – Dr. Debra Houry, Dr. Demetre Daskalakis and Dr. Daniel Jernigan – resigned from senior roles at the agency.

The officials returned to the office Thursday to collect their belongings, and staff members at the beleaguered agency had planned to gather in the afternoon to applaud them as they left the Atlanta campus. But their removal by security personnel earlier in the morning squelched those plans, according to current and former employees.

Houry and Daskalakis told The Associated Press that Monarez had tried to guard against political meddling in scientific research and health recommendations.

“We were going to see if she was able to weather the storm. And when she was not, we were done,” Houry said. She had been the agency’s deputy director and chief medical officer.

Daskalakis resigned as head of the National Center for Immunization and Respiratory Diseases and Jernigan from the National Center for Emerging and Zoonotic Infectious Diseases

If removed, Monarez will be the shortest-serving director since the CDC was founded in 1946, exacerbating a leadership vacuum that has persisted since Trump took office. He initially chose David Weldon, a former Florida congressman who is a doctor and vaccine skeptic, but yanked the nomination in March.

Monarez, a longtime government scientist, was tapped next to lead the $9.2 billion agency while she was serving as its interim director. But questions immediately emerged within Kennedy’s circle about her loyalty to the “Make America Healthy Again” movement, especially given her previous support of the COVID-19 vaccines that Kennedy has routinely criticized.

Kennedy rarely mentioned Monarez by name in the way he did other health agency leaders such s Mehmet Oz of the Centers for Medicare and Medicaid Services or Marty Makary of the Food and Drug Administration.

A flashpoint has been Kennedy’s handling of the CDC’s advisory vaccine committee, which he has tried to reshape since taking over the Department of Health and Human Services.

The panel is expected to meet next month, and Sen. Bill Cassidy, R-La., said any recommendations issued then will be “lacking legitimacy.”

“Serious allegations have been made about the meeting agenda, membership, and lack of scientific process being followed,” said Cassidy, who heads the Senate committee overseeing Kennedy’s department. He added that “these decisions directly impact children’s health and the meeting should not occur until significant oversight has been conducted.”

Cassidy, a doctor, provided crucial support for Kennedy’s nomination after saying Kennedy had assured him that he would not topple the nation’s childhood vaccination program.

The Advisory Committee on Immunization Practices is a group of outside experts who make recommendations to the CDC director on how to use vaccines. The recommendations are then adopted by doctors, school systems, health insurers and others.

Kennedy is a longtime leader in the anti-vaccine movement, and in June, he abruptly dismissed the entire panel, accusing members of being too closely aligned with manufacturers. He replaced them with a group that included several vaccine skeptics and then he shut the door to several doctors organizations that had long helped form vaccine recommendations.

Houry and Daskalakis said Monarez had tried to make sure scientific safeguards were in place.

For example, she tried to replace the official who coordinated the panel’s meetings with someone who had more policy experience. Monarez also pushed to have slides and evidence reviews posted weeks before the committee’s meetings and have the sessions open to public comment, Houry said.

HHS officials nixed that and called Monarez to a meeting in Washington on Monday, Houry said.

Daskalakis described the situation as untenable.

“I came to the point personally where I think our science will be compromised, and that’s my line in the sand,” he said.

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Seitz and Megerian reported from Washington.

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