The disappearance of Nancy Guthrie, mother of NBC “Today” co-host Savannah Guthrie, has left Arizona officials and the community grappling with limited information. Over the weekend, 84-year-old Nancy vanished from her Tucson residence under what authorities describe as suspicious circumstances.

According to the Pima County Sheriff’s Department, Nancy was last observed at her home around 9:30 p.m. on Saturday. Sheriff Chris Nanos confirmed on Monday that a crime is indeed involved, although details remain sparse. As of Tuesday, Nanos could only confirm that the search for Nancy is ongoing, with investigators focusing on the area surrounding her last known location.

Nancy Guthrie’s disappearance has raised significant concern due to her health issues, which require medication within a 24-hour window to prevent potentially fatal consequences. This fact has led authorities to conclude that she did not leave on her own volition, given her limited mobility.

A photo released by NBC shows Nancy Guthrie alongside her daughter Savannah, a poignant reminder of the personal impact of this unfolding situation. As the search continues, the community and those following the story hope for a swift resolution.

An undated photo of Nancy Guthrie and Savannah Guthrie provided by NBC in response to the disappearance of the 84-year-old mother of the “Today” show host. (Courtesy of NBC)

Nanos previously said Nancy Guthrie did not leave the home by herself, pointing to her limited mobility and a health condition that could prove to be fatal if the necessary medication was not taken within 24 hours. 

Additionally, blood was later found inside Nancy Guthrie’s home, according to the Los Angeles Times. A law enforcement source told Fox News Digital that there were “blood drops” leading from the entryway outside down the house’s pathway towards the driveway.

When asked about the blood on Tuesday, however, Nanos told reporters that evidence from inside the house was still being tested and nothing found had pointed to a suspect. Investigators also found signs of forced entry into the home. 

“I’m not saying there’s blood inside that house or outside that house,” Nanos said while declining to elaborate on what evidence was collected from the home. 

Tuesday’s press conference ended with more questions than answers about Nancy Guthrie’s disappearance, a development that is concerning to experts who emphasize that the public can be one of law enforcement’s most valuable tools in finding missing persons.

An undated photo of Nancy Guthrie provided by NBC in response to the disappearance of the 84-year-old mother of “Today” show host, Savannah Guthrie. (Courtesy of NBC)

“It’s really unfortunate that very little has been provided to the public,” Callahan Walsh, “America’s Most Wanted” co-host, told Fox News Digital. “I was hoping at this press conference that something would be released – a break in the investigation, a direction that they’re headed, some hope for the family or actionable information for the public to assist. There just wasn’t any of that. It was mostly questions that were being asked by the media, and pretty vague or no answers provided.” 

During Tuesday’s press conference, Nanos did not offer a clear answer when asked if Nancy Guthrie had been targeted due to her daughter’s fame. 

“We’re looking at all the leads, and we don’t know,” Nanos said. “We’re going to assume both sides of that.”

The possibility is one that Walsh believes is not entirely unfounded. 

“It’s very possible that she was targeted because of who her daughter is,” Walsh said. “Her daughter’s a high-profile television personality on the ‘Today’ show somebody that people see in their homes and on their television screens regularly. There absolutely could be somebody out there that has a grudge against Savannah and has taken it out on her mother, and let’s hope that’s not the case.”

Exteriors of missing person Nancy Guthrie’s home on Tuesday, February 3, 2026, in Tucson, Arizona. Nancy Guthrie, mother of “Today” show host Savannah Guthrie, is suspected of being abducted from her home earlier this week. (Derek Shook for Fox News Digital)

During an interview on MSNOW on Tuesday, Nanos said Nancy Guthrie was “physically removed from that home against her will,” but declined to say whether she was harmed. The sheriff also said it’s unknown if the individual who took Nancy Guthrie is familiar or a stranger.

Nancy Guthrie’s cell phone, Apple Watch, wallet and car keys were also found inside the home following her disappearance. 

Walsh points to several key details that could indicate whether the kidnapper was known to Nancy Guthrie, given the current publicized facts surrounding her disappearance and the fact that she was taken from the home. 

“That could indicate she was compliant,” Walsh told Fox News Digital. “And that means either she possibly knew the abductor, or that the abductor used some sort of threatening tactic – a weapon of some sort that brought her into compliance, and she thought she was safer going with them.” 

Shortly after Tuesday’s press conference, the Pima County Sheriff’s Department revealed it is “aware” of reports of an alleged ransom note after TMZ reportedly received written correspondence demanding a “substantial amount” of money in exchange for Guthrie’s return. 

WATCH: Police investigating possible Nancy Guthrie ransom note: Report

“We are aware of reports circulating about possible ransom note(s) regarding the investigation into Nancy Guthrie,” the officials wrote in a statement Tuesday afternoon. 

“Anything that comes in, goes directly to our detectives who are coordinating with the FBI,” officials wrote.

As officials continue to investigate and search for Nancy Guthrie, Walsh emphasizes the important role the public can play in missing persons cases when every second counts. 

“I think they really need to lean into the power of the public and harness whatever evidence, or share whatever information that they have so that the public can assist,” Walsh said, adding, “My biggest hope is that once they do start finding information that the public can assist with, that they release that information and that information can acted upon.” 

The Pima County Sheriff’s Office is providing a reward up to $2,500 for information relating to the disappearance of Nancy Guthrie.

People with information about Nancy Guthrie’s disappearance are asked to contact the Pima County Sheriff’s Department at 520-351-4900.