TUCSON, Ariz. – Savannah Guthrie, a co-host on NBC’s “Today,” along with her siblings, has issued a heartfelt appeal on Instagram concerning the disappearance of their mother, Nancy Guthrie. They are urging anyone who might be involved in her abduction to make contact, as Arizona authorities indicate potential criminal activity and a possible ransom situation.

Savannah Guthrie began the family’s emotional message by expressing gratitude for the public’s prayers and support. She described her mother as the family’s cornerstone and made a direct plea for communication, highlighting Nancy Guthrie’s delicate health and the critical need for her medication.

“Our mom is a remarkable woman filled with kindness, faith, and unwavering love,” Savannah Guthrie shared. “She’s lively and amusing, cherished by her grandchildren who shower her with affection. She embraces fun and adventure, is a steadfast friend, and exudes both warmth and wisdom. Just a conversation with her reveals her true essence.”

“She is central to our family, both in spirit and home,” she continued. “Her health is precarious, and she’s without her essential medication. It’s vital for her survival and comfort. We are aware of the media reports about a ransom note and as a family, we are doing everything possible.”

Savannah, along with her siblings Annie and Cameron, reached out on Instagram, urging anyone with details on Nancy Guthrie’s whereabouts to step forward. (Source: Instagram/@SavannahGuthrie/Today)

“We are prepared to communicate,” she added, “but in today’s world, where voices and images can be easily altered, we need undeniable proof that she is alive and with you. We are eager for contact and willing to engage. Please, reach out to us.”

Annie Guthrie then spoke through tears, appealing directly to her mother and laying bare the family’s desperation as the search continues, saying, “We are always going to be merely human, just normal human people who need our mom. Momma. Momma, if you’re listening, we need you to come home. We miss you.”

Savannah Guthrie later addressed her mother directly, offering words of faith and reassurance as the family waits for answers.

“Mommy? If you are hearing this, you are a strong woman,” she said. “You are God’s precious daughter, Nancy. We believe and know that even in this valley, He is with you. Everyone is looking for you, Mommy, everywhere. We will not rest, your children will not rest until we are together again. We speak to you every moment, and we pray without ceasing, and we rejoice in advance for the day that we hold you in our arms again. We love you.”

President Donald Trump also offered a major helping hand in the search for Nancy Guthrie on Wednesday night.

“I spoke with Savannah Guthrie, and let her know that I am directing ALL Federal Law Enforcement to be at the family’s, and Local Law Enforcement’s, complete disposal, IMMEDIATELY,” he wrote on Truth Social. “We are deploying all resources to get her mother home safely. The prayers of our Nation are with her and her family. GOD BLESS AND PROTECT NANCY!”

Earlier in the day, investigators returned to the home of Savannah Guthrie’s mother in Arizona as they continue to aggressively seek tips.

Deputies with the Pima County Sheriff’s Department were seen back at Nancy Guthrie’s home on Wednesday afternoon, putting up yellow crime scene tape. K-9s were also brought to the home, but it’s unclear why law enforcement returned to the home four days after Nancy Guthrie’s disappearance. The Pima County Sheriff’s Department said in a tweet it was “conducting follow-up’ at the home, offering no details.

Several people who appeared to be law enforcement also showed up at Savannah Guthrie’s sister Annie Guthrie’s home on Wednesday. The home is just a few miles from Nancy Guthrie’s home. It’s unclear why they were there, but they brought some equipment inside.

Investigators arrive to the home of Annie Guthrie in Tuscon, Arizona, on Wednesday, February 4, 2026. Guthrie’s mother, Nancy Guthrie, has been missing since last being seen on Saturday night. (Derek Shook for Fox News Digital)

Nancy Guthrie, 84, was last seen at her Tucson residence at around 9:30 p.m. Saturday, according to the Pima County Sheriff’s Department. While officials didn’t immediately elaborate on the circumstances of her disappearance, Sheriff Chris Nanos said on Monday that “we do, in fact, have a crime.” A law enforcement source told Fox News Digital that there were “blood drops” leading from the entryway outside down the house’s pathway towards the driveway. 

Nanos said Nancy Guthrie didn’t attend her Sunday church service, adding that her family was notified about the absence by a churchgoer. Officials said family members went to Nancy Guthrie’s home at around 11 a.m. and spent some time looking for her. Her family called 911 at around noon. Nancy Guthrie had dinner with her daughter Annie and son-in-law, Tommaso Cioni, on Saturday evening, Nanos told The New York Times. He added that Cioni dropped Nancy Guthrie off at her home afterward and made sure she made it inside.

An undated photo of Nancy Guthrie and Savannah Guthrie provided by NBC in repsonse to the disappearance of the 84 year-old mother of the Today Show host. (Courtesy of NBC)

A Pima County Sheriff’s Office official told Fox News Digital on Monday that officials believe Nancy Guthrie was either kidnapped or abducted.

“Sheriff [Chris] Nanos has stated that he believes that a crime has been committed,” a spokesperson for Pima County Sheriff’s Office told Fox News Digital. “At this point, investigators believe she was taken from the home against her will and that includes possible kidnapping or abduction.”

During the Tuesday news conference, Nanos didn’t have an answer when asked if he knew where Nancy Guthrie was, saying he doesn’t know.

The sheriff declined to answer several questions, including one from a reporter who asked if there was a ransom demanded.

An undated photo of Nancy Guthrie provided by NBC in repsonse to the disappearance of the 84 year-old mother of Today Show host, Savannah Guthrie. (Courtesy of NBC)

“We are following all leads we have. That’s all I can tell you,” he said. “We’ve got hundreds of leads. And it’s from you that produced those leads by telling people we need help.”

When asked if the apparent abduction was targeted or random, Nanos repeated a similar answer.

“We’re going to assume both sides of that. We’ll look at both sides,” he said.

Following Tuesday’s news conference, the Pima County Sheriff’s Department revealed it is “aware” of reports of a possible ransom note after TMZ reportedly received written correspondence demanding a “substantial amount” of money in exchange for Guthrie’s return. 

An undated photo of Nancy Guthrie and Savannah Guthrie provided by NBC in repsonse to the disappearance of the 84 year-old mother of the Today Show host. (Courtesy of NBC)

Savannah Guthrie and mother Nancy Guthrie pictured on “Today” on Thursday, June 15, 2023. (Nathan Congleton/NBC via Getty Images)

The White House also commented on her disappearance, writing: “The search for Savannah Guthrie’s mother, Nancy Guthrie, is ongoing, and authorities are requesting assistance from the public. Anyone with information is urged to contact 911.”

“Our prayers are with the Guthrie family as we hope for Nancy’s safe return home,” the White House posted.

Savannah Guthrie spoke out on Instagram in a post on Monday, writing “We need you.”

Aerial drone shots of missing person Nancy Guthrie’s home on Tuesday, February 3, 2026 in Tucson, Arizona. Nancy Guthrie, mother of ‘Today’ show host Savannah Guthrie, is suspected of being abducted from her home earlier this week. (Fox Flight Team)

The Pima County Sheriff’s Office is asking anyone with information on the disappearance of Nancy Guthrie to call them or reach out via the QR code in this missing person flyer. (Pima County Sheriff’s Office)

“We believe in prayer. We believe in voices raised in unison, in love, in hope. We believe in goodness. We believe in humanity. Above all, we believe in Him,” she wrote. “Thank you for lifting your prayers with ours for our beloved mom, our dearest Nancy, a woman of deep conviction, a good and faithful servant. Raise your prayers with us and believe with us that she will be lifted by them in this very moment.”