Individuals on specific medications have been advised to reach out to their general practitioner (GP) “urgently” due to potential health risks. According to official NHS guidance, certain groups are cautioned against using these medications as they may pose health concerns.

Sodium valproate, a drug commonly prescribed under brand names like Dyzantil, Epilim, Episenta, or Epival, is primarily used for treating epilepsy and bipolar disorder. The medication is available in various forms, including capsules, tablets, liquid, and granules that can be mixed with food or drink for easier consumption.

As highlighted by Wales Online, the NHS guidance specifies: “This medicine is only available on prescription. If you’re under 55 years old, it must be prescribed by a specialist doctor, who will also need to obtain a second opinion from another specialist to confirm that no other suitable treatment options are available for you.”

Despite its benefits, the NHS strongly advises against the use of sodium valproate for certain groups. Notably, pregnant women are urged to avoid this medication. The NHS website cautions: “Sodium valproate is not recommended in pregnancy, as it can lead to birth defects and affect your child’s learning and behavior.”

The guidance further advises: “If there’s a possibility of becoming pregnant while on this medication, your doctor will enroll you in Prevent, the valproate pregnancy prevention programme. Should you suspect you are pregnant while taking sodium valproate, it is crucial to contact your doctor or nurse immediately.”

“If there’s a chance you could become pregnant while taking this medicine, your doctor will enrol you on Prevent, the valproate pregnancy prevention programme. If you think you might be pregnant and you’re taking sodium valproate, contact your doctor or nurse urgently.”

Anyone who becomes pregnant while taking the medication should consult their GP before stopping treatment. This is because discontinuing the medicine may cause the symptoms of their condition to deteriorate.

The guidance explains: “Your doctor may continue to prescribe sodium valproate, but only if there’s no other suitable treatment for your epilepsy or bipolar disorder. For pregnant women with recurrent migraine, your doctor should offer you an alternative treatment to sodium valproate.”

Meanwhile, men taking sodium valproate who are considering fatherhood should also speak with their doctor. The advise says: “For men who could possibly have children, it’s important to discuss sodium valproate with your doctor.

“You and your partner should use contraception while you’re taking sodium valproate and for at least three months after stopping. For men who are planning to start a family within the next year, speak to a doctor about your treatment options. Do not stop taking sodium valproate without speaking to a doctor first.”

The medication can also impact fertility in both men and women. The medication has been linked to infertility in men while it can also alter a woman’s menstrual cycle.

NHS guidance explains: “Do not stop or change your medicine without speaking to your doctor, as it may make your condition worse.”

It continues: “In women sodium valproate can change your menstrual cycle, causing delayed or missed periods. Sodium valproate has also been reported to cause polycystic ovary syndrome (PCOS), though this happens rarely.

“Talk to your doctor if you’re concerned about how sodium valproate may affect your fertility and pregnancy plans.”