Rep. Nancy Mace drew a swift fact-check after promoting legislation aimed at blocking federal funding for what she described as “radical transgender experiments” on mice — research critics noted is not actually taking place.
On Saturday, the congresswoman announced that she was introducing a new measure in Congress titled the “TRANS MICE Act.”
“Animals should not be used for radical transgender experiments. This is not science. This is ideological cruelty paid for by the American taxpayers,” Mace wrote.
She added that the bill would prohibit federal money from being used to “conduct, support, or fund research aimed at altering an animal’s biological sex.”
But a community note on X challenged the premise of her claim, explaining that the research in question involves transgenic mice — not “transgender” mice.
“‘Trans mice’ refers to transgenic mice not transgender mice,” the note stated.
The note further explained that transgenic mice are animals that have had foreign DNA incorporated into their genome, a common tool used to study gene function and disease mechanisms, including in cancer research.
Lame duck Congresswoman Nancy Mace faced criticism after promoting a bill targeting alleged federal funding for “radical transgender experiments” on mice.
On Saturday, Mace announced a new bill she was introducing in Congress called the ‘TRANS MICE Act’
Many on social media ripped Mace for the confusion.
‘It’s depressingly funny that these people don’t understand the word transgenic. Transgenic research is how we now have mass produced insulin,’ one wrote.
‘Nobody is making trans “gender” mice. Wtf.’
‘As someone who works with transgenic mouse models for cancer research, this is objectively one of the funniest things I’ve seen a real life politician post,’ added another.
Mace has since tried to play defense and said that people are reading her tweet the wrong way.
‘This post is not about transgenic mice. It is about federally funded transgender-related experiments on animals,’ she said.
‘The bill is called the Transgender Research on Animals Now Stops and Money for Ideological Cruelty Eliminated Act, also known as the TRANS MICE Act. The Community Note addresses “transgenic mice,” which is a completely different topic.’
It’s the latest downturn for Mace in what’s been a rough 2026 for the once rising Republican star.
An X community note pointed out that government experiments are run on transgenic mice, not transgender mice
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She was previously a key ally of Donald Trump and chose to abandon her seat to run for governor of South Carolina. She lost the Republican nomination to a candidate endorsed by the President.
The Congresswoman alleged that her support for the release of the Epstein files lost her Trump’s endorsement.
She will not run for Congress again, she told Politico earlier this month.
‘Headed back to the private sector at the end of this term,’ Mace posted on X last week. ‘When I ran in 2020 I said I’d only serve 3 terms and my time is up. It’s truly been an immense honor.’
Mace finished last in a field of five Republicans, trailing the two leaders by over 14 percentage points. Even in her home county of Charleston, she came in a distant third.
She owned the defeat, changing her private X bio to read, ‘just got my a** kicked in Governors race.’
Mace had made a bid for President Donald Trump’s endorsement, even labeling herself ‘Trump in high heels’ during a speech early in her gubernatorial campaign.
But Trump decided on a late endorsement for Evette instead.
Trump and Mace exchange greetings in March 2025. The pair have since had a falling out
She had a turbulent relationship with the President, distancing herself from him after his loss in the 2020 election and the subsequent Capitol riot on January 6, 2021.
She defeated a Trump-endorsed primary challenger in 2022 before somewhat making nice with the President, eventually endorsing him over South Carolinian presidential candidate Nikki Haley in the 2024 race.
During Trump’s second term, Mace and the President again parted ways.
The Congresswoman said her administration-defying push for publication of the Epstein files doomed her hopes of a Trump endorsement.
‘I know I put the likelihood of an endorsement on the line when I demanded transparency on the Epstein files,’ Mace wrote on X after Trump endorsed Evette.
‘I demanded it because you deserved the truth – ALL OF IT,’ she continued.
‘If sacrificing my values is the price of an endorsement, I will never pay it.’
In 2020, Mace gained entry into the U.S. Congress by unseating the Democrat who had represented her district.
‘People keep asking me: “Will you get revenge on Trump for ending your political career?”‘ she said on X last week.
‘The answer is yes. I’ll be adding to the unemployment number in January.’
