Two decades have passed since Jennifer Kesse’s mysterious disappearance, yet her parents, Drew and Joyce Kesse, remain steadfast in their search for answers, driven by the hope that new technological advancements may finally provide some clarity.

At just 24 years old, Jennifer vanished on January 24, 2006, after failing to appear at her job in Orlando, Florida. Marking this somber milestone, her parents shared their ongoing anguish with Fox News affiliate WTVT, emphasizing that time has not eased their pain or brought closure to their lives.

“We look for Jennifer pretty much every day,” they expressed. “It feels like an eternity. We are still living in a surreal state.”

In a renewed effort to solve the case, Florida investigators have intensified their search efforts, revisiting the circumstances surrounding Jennifer’s disappearance on that fateful January day in 2006.

Her abandoned car was discovered about a mile from her home, with surveillance footage capturing a person of interest parking the vehicle and walking away. Unfortunately, the video did not reveal the individual’s face, leaving investigators with limited leads.

Drew Kesse recounted how, upon learning that Jennifer had missed work, he immediately attempted to contact her, adhering to a family agreement that they would always respond to each other’s calls. However, his efforts were met with disheartening silence, as Jennifer’s phone went directly to voicemail.

“I knew something was wrong immediately,” Kesse said. 

Jennifer Kesse, 24, was reported missing after she failed to show up for her work on Jan. 24, 2006. (WTTV)

Drew and Joyce made the two-hour drive from their home in Tampa to Orlando, where they found their daughter’s apartment empty with several outfit choices laid out on her bed. 

The parents immediately called the Orlando Police Department (OPD) to report Jennifer missing. 

“They looked around her apartment, shrugged their shoulders and said, ‘She had a fight with her boyfriend probably, she’ll be back,’” Kesse said. “They walked out. And that was Jennifer’s last chance.”

The Kesses later sued OPD to gain access to Jennifer’s case file, which spans more than 16,000 pages.

“It exhausts you. It drains you physically, mentally and emotionally, and it will in time take a toll on your actual physical health,” they told FOX 13.

With the Florida Department of Law Enforcement (FDLE) now overseeing the case, the Kesses said they are pursuing new investigative approaches, including working with an artificial intelligence firm to analyze the case file and surveillance video.

One focus has been on identifying the person of interest through physical characteristics visible in the video.

“An ear is just like an eye or a fingerprint. It’s very unique to a person,” Drew said. “When we find the ear, then we’ve found the person.”

Jennifer Kesse and her father, Drew, open presents in an undated family photo. (Courtesy of the Kesse Family )

The Kesses also said new DNA samples were tested last year and that investigators are closer than ever to identifying several people they would like to speak with.

As they continue to wait for answers, Jennifer’s parents said they still believe she was taken shortly after disappearing.

“I personally still think that Jennifer was taken and taken out of the area — state and maybe country — very quickly,” her father said, adding that he believes she may have been targeted because she was alone.

Drew and Joyce shared with Fox News affiliate WTTV that they will never stop searching for their daughter, Jennifer, who disappeared on Jan. 24, 2006. (KTTV)

Now nearing 70, Jennifer’s parents said their determination has not faded since the search began two decades ago.

“Till we die,” Joyce said. “Whatever it takes. There’s no quit in us.”

Jennifer Kesse smiles alongside her mother, Joyce. (Courtesy of the Kesse Family )

Anyone with information about Jennifer’s disappearance is encouraged to contact FDLE’s Orlando office at (407) 245-0888 or OROCColdCaseTips@fdle.state.fl.us.

The OPD and the FDLE did not immediately respond to Fox News Digital’s request for comment.