WASHINGTON — The Supreme Court on Monday will examine the Biden administration’s objection to the bankruptcy reorganization of opioid maker Purdue Pharma, which includes a provision that protects the Sackler family from liability from future lawsuits.

It is no ordinary bankruptcy case, touching as it does upon the nationwide harm caused by the opioid crisis and the role that Sackler-owned Purdue played in creating it.

As part of the proposed deal, which the Supreme Court put on hold in August, the Sackler family had agreed to pay around $6 billion that could be used to settle opioid-related claims, but only in return for a complete release from any liability in future cases.

The overall settlement, including assets held by Purdue, is likely to be worth significantly more, with the reorganized company set to dedicate itself to tackling the impact of opioid abuse.

No Sackler family member has had any involvement in the company since 2019.

During oral arguments on Monday, the justices will probe whether the bankruptcy court had the authority to release the Sackler family members from the claims being made by opioid victims.

Purdue made billions from OxyContin, a widely available painkiller that fueled the opioid epidemic. The company’s tactics in aggressively marketing the drug came under increasing scrutiny as thousands of people died from opioid overdoses in recent years.

The company sought bankruptcy protection, but the Sackler family members did not. Instead, they negotiated a separate deal with Purdue and plaintiffs in pending lawsuits that would allow the company to reinvent itself to address the opioid crisis.

The Biden administration objects to the release of additional claims against the Sacklers, saying it would be unfair to potential future plaintiffs.

Solicitor General Elizabeth Prelogar wrote in a court filing that the settlement prevents the Sacklers from facing “claims alleging damages in the trillions” while “keeping billions of dollars that they siphoned from Purdue.”

In a May decision, the New York-based 2nd U.S. Circuit Court of Appeals approved the plan over the objection of William Harrington, the U.S. government trustee monitoring the bankruptcy. The Justice Department’s trustee program, of which Harrington is part, is aimed at ensuring that the bankruptcy system operates as required under law.

Purdue has criticized Harrington’s role, noting that groups representing thousands of plaintiffs have signed on to the settlement, which could not have happened without the Sackler family contribution.

“This intense, yearslong process culminated in a series of interlocking agreements dependent on the multibillion-dollar settlement reached with the Sacklers,” Purdue lawyers said in court papers.

At the Supreme Court, various groups representing plaintiffs are supporting Purdue, including one that includes 1,300 cities, counties and other municipalities, and another representing 60,000 individuals affected by the opioid epidemic.

In one brief filed by a group representing a large array of plaintiffs, lawyers wrote that their clients “have no love lost for the Sacklers” but recognize that the settlement is “the only means of getting billions of dollars in life-changing and live-saving funds … that are desperately needed today.”

Canadian municipalities and Indigenous First Nations are among those objecting to the settlement.

Purdue flourished under brothers Mortimer and Raymond Sackler, who died in 2010 and 2017, respectively. The family reaped billions and spent lavishly, including on splashy charitable projects.

The family told the Supreme Court that it continues to back the settlement.

In a brief filed on behalf of the relatives of Mortimer Sackler, most of whom are based overseas, lawyers warned of “significant litigation costs and risks” in seeking to enforce any foreign court judgments against the family if the settlement were thrown out.